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  • 1
    ISSN: 1432-1424
    Keywords: Cerebellar granule neuron ; Heloderma horridum ; Helothermine ; Potassium current ; Patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Helothermine, a recently isolated toxin from the venom of the Mexican beaded lizard Heloderma horridum horridum was tested on K+ currents of newborn rat cerebellar granule cells. In whole-cell voltageclamp experiments, cerebellar granule neurons exhibited at least two different K+ current components: a first transient component which is similar to an I A-type current, is characterized by fast activating and inactivating kinetics and blocked by 4-aminopyridine; a second component which is characterized by noninactivating kinetics, is blocked by tetraetylammonium ions and resembles the classical delayed-rectifier current. When added to the standard external solution at concentrations ranging between 0.1 and 2 μm helothermine reduced the pharmacologically isolated I A-type current component in a voltage- and dose-dependent way, with a half-maximal inhibitory concentration (IC50) of 0.52 μm. A comparison between control and nelothermine-modified peak transient currents shows a slowdown of activation and inactivation kinetics. The delayed-rectifier component inhibition was concentration dependent (IC50 = 0.86 μm) but not voltage dependent. No frequency-or use-dependent block was observed on both K+ current types. Perfusing the cells with control solution resulted in quite a complete current recovery. We conclude that helothermine acts with different affinities on two types of K+ current present in central nervous system neurons.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2021-09-03
    Description: The Iberian Peninsula and the Maghreb experience moderate earthquake activity and oblique, ∼ NW–SE convergence between Africa and Eurasia at a rate of ∼ 5 mm/yr. Coeval extension in the Alboran Basin and a N35°E trending band of active, left-lateral shear deformation in the Alboran–Betic region are not straightforward to understand in the context of regional shortening, and evidence complexity of deformation at the plate contact. We estimate 86 seismic moment tensors (MW 3.3 to 6.9) from time domain inversion of near-regional waveforms in an intermediate period band. Those and previous moment tensors are used to describe regional faulting style and calculate average stress tensors. The solutions associated to the Trans-Alboran shear zone show predominantly strike-slip faulting, and indicate a clockwise rotation of the largest principal stress orientation compared to the regional convergence direction (σ1 at N350°E). At the N-Algerian and SW-Iberian margins, reverse faulting solutions dominate, corresponding to N350°E and N310°E compression, respectively. Over most of the Betic range and intraplate Iberia, we observe predominately normal faulting, and WSW–ENE extension (σ3 at N240°E). From GPS observations we estimate that more than 3 mm/yr of African (Nubian)–Eurasian plate convergence are currently accommodated at the N-Algerian margin, ∼ 2 mm/yr in the Moroccan Atlas, and ∼ 2 mm/yr at the SW-Iberian margin. 2 mm/yr is a reasonable estimate for convergence within the Alboran region, while Alboran extension can be quantified as ∼ 2.5 mm/yr along the stretching direction (N240°E). Superposition of both motions explains the observed left-lateral transtensional regime in the Trans-Alboran shear zone. Two potential driving mechanisms of differential motion of the Alboran–Betic–Gibraltar domain may coexist in the region: a secondary stress source other than plate convergence, related to regional-scale dynamic processes in the upper mantle of the Alboran region, as well as drag from the continental-scale motion of the Nubian plate along the southern limit of the region. In the Atlantic Ocean, the ∼ 3.5 mm/ yr, westward motion of the Gibraltar Arc relative to intraplate Iberia can be accommodated at the transpressive SW-Iberian margin, while available GPS observations do not support an active subduction process in this area.
    Description: Published
    Description: 295-317
    Description: JCR Journal
    Description: reserved
    Keywords: GPS ; Kinematics ; 04. Solid Earth::04.02. Exploration geophysics::04.02.06. Seismic methods
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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