Publication Date:
2003-11-15
Description:
Prefoldins (PFDs) are members of a recently identified, small-molecular weight protein family able to assemble into molecular chaperone complexes. Here we describe an unusually large member of this family, termed URI, that forms complexes with other small-molecular weight PFDs and with RPB5, a shared subunit of all three RNA polymerases. Functional analysis of the yeast and human orthologs of URI revealed that both are targets of nutrient signaling and participate in gene expression controlled by the TOR kinase. Thus, URI is a component of a signaling pathway that coordinates nutrient availability with gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gstaiger, Matthias -- Luke, Brian -- Hess, Daniel -- Oakeley, Edward J -- Wirbelauer, Christiane -- Blondel, Marc -- Vigneron, Marc -- Peter, Matthias -- Krek, Wilhelm -- New York, N.Y. -- Science. 2003 Nov 14;302(5648):1208-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institut, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14615539" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Amino Acids/*metabolism
;
Carrier Proteins/chemistry/genetics/*metabolism
;
Cell Line
;
DNA-Binding Proteins/metabolism
;
DNA-Directed RNA Polymerases/metabolism
;
GATA Transcription Factors
;
*Gene Expression Regulation/drug effects
;
Humans
;
*Intracellular Signaling Peptides and Proteins
;
Molecular Sequence Data
;
Phosphorylation
;
Protein Kinases/metabolism
;
Protein Subunits/metabolism
;
RNA Interference
;
Repressor Proteins/metabolism
;
Saccharomyces cerevisiae/*genetics/metabolism
;
Saccharomyces cerevisiae Proteins/metabolism
;
*Signal Transduction
;
Sirolimus/pharmacology
;
TOR Serine-Threonine Kinases
;
Trans-Activators/metabolism
;
Transcription Factors/metabolism
;
*Transcription, Genetic/drug effects
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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