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  • *Trans-Activators  (2)
  • American Association for the Advancement of Science (AAAS)  (2)
  • Oxford University Press
  • American Chemical Society (ACS)
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  • American Association for the Advancement of Science (AAAS)  (2)
  • Oxford University Press
  • American Chemical Society (ACS)
Years
  • 1
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    Teratogen-mediated inhibition of target tissue response to Shh signaling (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-11
    Description: Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent teratogens capable of inducing cyclopia and other birth defects. Here, it is shown that these compounds specifically block the Sonic hedgehog (Shh) signaling pathway. These teratogens did not prevent the sterol modification of Shh during autoprocessing but rather inhibited the response of target tissues to Shh, possibly acting through the sterol sensing domain within the Patched protein regulator of Shh response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, M K -- Porter, J A -- Young, K E -- Beachy, P A -- New York, N.Y. -- Science. 1998 Jun 5;280(5369):1603-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9616123" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/etiology ; Animals ; Cell Membrane/metabolism ; Central Nervous System/drug effects/*embryology/metabolism ; Chick Embryo ; Cholesterol/biosynthesis/*metabolism ; Culture Techniques ; DNA-Binding Proteins/biosynthesis ; Endoplasmic Reticulum/metabolism ; Hedgehog Proteins ; Hepatocyte Nuclear Factor 3-beta ; Holoprosencephaly/chemically induced ; Homeodomain Proteins/biosynthesis ; LIM-Homeodomain Proteins ; Membrane Proteins/metabolism ; Muscle Proteins/biosynthesis ; Nerve Tissue Proteins/biosynthesis ; Nuclear Proteins/biosynthesis ; PAX7 Transcription Factor ; Proteins/*metabolism ; Receptors, Cell Surface ; Signal Transduction/drug effects ; Teratogens/*pharmacology ; Tomatine/analogs & derivatives/pharmacology ; *Trans-Activators ; *Transcription Factors ; Triparanol/pharmacology ; Veratrum Alkaloids/*pharmacology ; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Cholesterol modification of hedgehog signaling proteins in animal development (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-11
    Description: Hedgehog (Hh) proteins comprise a family of secreted signaling molecules essential for patterning a variety of structures in animal embryogenesis. During biosynthesis, Hh undergoes an autocleavage reaction, mediated by its carboxyl-terminal domain, that produces a lipid-modified amino-terminal fragment responsible for all known Hh signaling activity. Here it is reported that cholesterol is the lipophilic moiety covalently attached to the amino-terminal signaling domain during autoprocessing and that the carboxyl-terminal domain acts as an intramolecular cholesterol transferase. This use of cholesterol to modify embryonic signaling proteins may account for some of the effects of perturbed cholesterol biosynthesis on animal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, J A -- Young, K E -- Beachy, P A -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):255-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8824192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; Cholesterol/*metabolism ; Dithiothreitol/pharmacology ; Drosophila ; *Drosophila Proteins ; *Embryonic Induction ; Embryonic and Fetal Development ; Hedgehog Proteins ; Humans ; Protein Processing, Post-Translational ; Proteins/genetics/*metabolism ; Signal Transduction ; *Trans-Activators
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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