Publikationsdatum:
2003-06-07
Beschreibung:
Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy. IL-4 can stimulate two receptors, type I and type II, whereas IL-13 signaling is mediated only by the type II receptor (see the STKE Connections Maps). These cytokines activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelly-Welch, Ann E -- Hanson, Erica M -- Boothby, Mark R -- Keegan, Achsah D -- AI38985/AI/NIAID NIH HHS/ -- AI45662/AI/NIAID NIH HHS/ -- AI49460/AI/NIAID NIH HHS/ -- GM42550/GM/NIGMS NIH HHS/ -- HL61752/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2003 Jun 6;300(5625):1527-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, and the Institute for Biomedical Sciences, George Washington Medical Center, Washington, DC 20037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12791978" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Amino Acid Motifs
;
Animals
;
Asthma/immunology/metabolism
;
Humans
;
Hypersensitivity/immunology/metabolism
;
Interleukin-13/*metabolism
;
Interleukin-13 Receptor alpha1 Subunit
;
Interleukin-4/*metabolism
;
Lymphocyte Activation
;
Phosphatidylinositol 3-Kinases/metabolism
;
Phosphoproteins/metabolism
;
Phosphorylation
;
Phosphotyrosine/metabolism
;
Protein Structure, Tertiary
;
Protein-Tyrosine Kinases/metabolism
;
Receptors, Antigen, T-Cell/immunology/metabolism
;
Receptors, Interleukin/chemistry/metabolism
;
Receptors, Interleukin-13
;
Receptors, Interleukin-4/chemistry/metabolism
;
STAT6 Transcription Factor
;
*Signal Transduction
;
T-Lymphocytes/immunology
;
Trans-Activators/metabolism
;
src Homology Domains
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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