Publication Date:
2002-08-06
Description:
Excessive caloric intake is thought to be sensed by the brain, which then activates thermogenesis as a means of preventing obesity. The sympathetic nervous system, through beta-adrenergic receptor (betaAR) action on target tissues, is likely the efferent arm of this homeostatic mechanism. To test this hypothesis, we created mice that lack the three known betaARs (beta-less mice). beta-less mice on a Chow diet had a reduced metabolic rate and were slightly obese. On a high-fat diet, beta-less mice, in contrast to wild-type mice, developed massive obesity that was due entirely to a failure of diet-induced thermogenesis. These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bachman, Eric S -- Dhillon, Harveen -- Zhang, Chen-Yu -- Cinti, Saverio -- Bianco, Antonio C -- Kobilka, Brian K -- Lowell, Bradford B -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):843-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161655" target="_blank"〉PubMed〈/a〉
Keywords:
Adipose Tissue, Brown/drug effects/metabolism
;
Animals
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Basal Metabolism/drug effects
;
Body Temperature/drug effects
;
Body Weight/drug effects/genetics
;
*Diet
;
Dietary Fats/administration & dosage/pharmacology
;
Energy Intake
;
Female
;
Homeostasis/drug effects
;
Immunohistochemistry
;
Male
;
Mice
;
Mice, Knockout
;
Obesity/blood/genetics/*metabolism/prevention & control
;
Oxygen Consumption/drug effects
;
Phenotype
;
Receptors, Adrenergic, beta/genetics/*metabolism
;
*Signal Transduction/drug effects
;
Sympathetic Nervous System/drug effects/physiology
;
Thermogenesis/genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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