Publication Date:
2012-11-20
Description:
Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327988/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327988/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huey, Daniel J -- Hu, Jerry C -- Athanasiou, Kyriacos A -- R01 AR047839/AR/NIAMS NIH HHS/ -- R01 AR053286/AR/NIAMS NIH HHS/ -- R01 DE015038/DE/NIDCR NIH HHS/ -- R01 DE019666/DE/NIDCR NIH HHS/ -- R01AR053286/AR/NIAMS NIH HHS/ -- R01DE015038/DE/NIDCR NIH HHS/ -- R01DE019666/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):917-21. doi: 10.1126/science.1222454.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23161992" target="_blank"〉PubMed〈/a〉
Keywords:
Biomechanical Phenomena
;
Bone Regeneration
;
Bone and Bones/physiology
;
Cartilage, Articular/*physiology
;
Humans
;
Mesenchymal Stromal Cells/physiology
;
Osteoblasts/physiology
;
Osteoclasts/physiology
;
*Regeneration
;
Tissue Engineering/*methods
;
*Tissue Scaffolds
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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