Publication Date:
2002-12-14
Description:
Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection. Regeneration occurs through robust proliferation of cardiomyocytes localized at the leading epicardial edge of the new myocardium. The hearts of zebrafish with mutations in the Mps1 mitotic checkpoint kinase, a critical cell cycle regulator, failed to regenerate and formed scars. Thus, injury-induced cardiomyocyte proliferation in zebrafish can overcome scar formation, allowing cardiac muscle regeneration. These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poss, Kenneth D -- Wilson, Lindsay G -- Keating, Mark T -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2188-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA. kposs@enders.tch.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481136" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blood Coagulation
;
Bromodeoxyuridine/metabolism
;
*Cell Division
;
Collagen/analysis
;
Fibrin
;
Fibrosis
;
Gene Expression Regulation
;
Heart/*physiology
;
Heart Injuries/pathology/physiopathology
;
Heart Ventricles/pathology/surgery
;
Mitosis
;
Models, Biological
;
Mutation
;
Myocardial Contraction
;
Myocardium/metabolism/pathology
;
Myocytes, Cardiac/*physiology
;
Protein-Serine-Threonine Kinases/genetics/physiology
;
Protein-Tyrosine Kinases/genetics/physiology
;
*Regeneration/genetics/physiology
;
Time Factors
;
Ventricular Function
;
Zebrafish/genetics/*physiology
;
*Zebrafish Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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