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  • 1
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    Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-11-21
    Description: Inflammatory hepatocellular adenomas are benign liver tumours defined by the presence of inflammatory infiltrates and by the increased expression of inflammatory proteins in tumour hepatocytes. Here we show a marked activation of the interleukin (IL)-6 signalling pathway in this tumour type; sequencing candidate genes pinpointed this response to somatic gain-of-function mutations in the IL6ST gene, which encodes the signalling co-receptor gp130. Indeed, 60% of inflammatory hepatocellular adenomas harbour small in-frame deletions that target the binding site of gp130 for IL-6, and expression of four different gp130 mutants in hepatocellular cells activates signal transducer and activator of transcription 3 (STAT3) in the absence of ligand. Furthermore, analysis of hepatocellular carcinomas revealed that rare gp130 alterations are always accompanied by beta-catenin-activating mutations, suggesting a cooperative effect of these signalling pathways in the malignant conversion of hepatocytes. The recurrent gain-of-function gp130 mutations in these human hepatocellular adenomas fully explains activation of the acute inflammatory phase observed in tumourous hepatocytes, and suggests that similar alterations may occur in other inflammatory epithelial tumours with STAT3 activation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695248/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695248/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rebouissou, Sandra -- Amessou, Mohamed -- Couchy, Gabrielle -- Poussin, Karine -- Imbeaud, Sandrine -- Pilati, Camilla -- Izard, Tina -- Balabaud, Charles -- Bioulac-Sage, Paulette -- Zucman-Rossi, Jessica -- AI055894/AI/NIAID NIH HHS/ -- AI067949/AI/NIAID NIH HHS/ -- GM071596/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Jan 8;457(7226):200-4. doi: 10.1038/nature07475. Epub 2008 Nov 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Inserm, U674, Genomique fonctionnelle des tumeurs solides, Paris F-75010, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19020503" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma, Liver Cell/*genetics/*pathology ; Cell Line, Tumor ; Cytokine Receptor gp130/*genetics/*metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Inflammation/genetics/pathology ; Interferons/metabolism ; Interleukin-6/metabolism ; STAT3 Transcription Factor/metabolism ; Sequence Deletion/*genetics ; Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-09
    Description: E6 viral oncoproteins are key players in epithelial tumors induced by papillomaviruses in vertebrates, including cervical cancer in humans. E6 proteins target many host proteins by specifically interacting with acidic LxxLL motifs. We solved the crystal structures of bovine (BPV1) and human (HPV16) papillomavirus E6 proteins bound to LxxLL peptides from the focal adhesion protein paxillin and the ubiquitin ligase E6AP, respectively. In both E6 proteins, two zinc domains and a linker helix form a basic-hydrophobic pocket, which captures helical LxxLL motifs in a way compatible with other interaction modes. Mutational inactivation of the LxxLL binding pocket disrupts the oncogenic activities of both E6 proteins. This work reveals the structural basis of both the multifunctionality and the oncogenicity of E6 proteins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899395/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899395/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zanier, Katia -- Charbonnier, Sebastian -- Sidi, Abdellahi Ould M'hamed Ould -- McEwen, Alastair G -- Ferrario, Maria Giovanna -- Poussin-Courmontagne, Pierre -- Cura, Vincent -- Brimer, Nicole -- Babah, Khaled Ould -- Ansari, Tina -- Muller, Isabelle -- Stote, Roland H -- Cavarelli, Jean -- Vande Pol, Scott -- Trave, Gilles -- CA08093/CA/NCI NIH HHS/ -- CA120352/CA/NCI NIH HHS/ -- CA134737/CA/NCI NIH HHS/ -- P30 CA044579/CA/NCI NIH HHS/ -- R01 CA134737/CA/NCI NIH HHS/ -- R01CA134737/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2013 Feb 8;339(6120):694-8. doi: 10.1126/science.1229934.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biotechnologie et Signalisation Cellulaire UMR 7242, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sebastien Brant, BP 10413, F-67412 Illkirch, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23393263" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Bovine papillomavirus 1 ; Crystallography, X-Ray ; Human papillomavirus 16 ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Oncogene Proteins, Viral/*chemistry/genetics/*metabolism ; Paxillin/*chemistry/metabolism ; Peptide Fragments/chemistry/metabolism ; Point Mutation ; *Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Repressor Proteins/*chemistry/genetics/*metabolism ; Ubiquitin-Protein Ligases/*chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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