Publication Date:
1981-09-18
Description:
Chiral recognition by nucleosides and nucleotides coated on silica gel was studied by high-performance liquid chromatography. Helicenes, which are chiral polyaromatic hydrocarbons, were used as probes. Stereoselectivity was detected when the nucleobase was a purine (adenosine 3', 5'-monophosphate, an guanosine), but was not detected with the pyrimidine derivative uridine. For a given nucleobase (adenine), all changes in the ribose moiety affected the resolution factors, which ranged between 1.03 and 1.074. These results might be relevant to the enantioselectivity of carcinogenic metabolites of polyaromatic hydrocarbons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Y H -- Tishbee, A -- Gil-Av, E -- New York, N.Y. -- Science. 1981 Sep 18;213(4514):1379-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268441" target="_blank"〉PubMed〈/a〉
Keywords:
Chemistry, Physical
;
Chromatography, High Pressure Liquid
;
*Nucleosides
;
*Nucleotides
;
Physicochemical Phenomena
;
*Polycyclic Compounds
;
Stereoisomerism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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