Publication Date:
2014-07-12
Description:
During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soroldoni, Daniele -- Jorg, David J -- Morelli, Luis G -- Richmond, David L -- Schindelin, Johannes -- Julicher, Frank -- Oates, Andrew C -- 098025/Wellcome Trust/United Kingdom -- MC_UP_1202/3/Medical Research Council/United Kingdom -- WT098025MA/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2014 Jul 11;345(6193):222-5. doi: 10.1126/science.1253089.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany. Medical Research Council (MRC)-National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK. Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. ; Max Planck Institute for the Physics of Complex Systems, Nothnitzer Strasse 38, 01187 Dresden, Germany. ; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany. Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Fisica de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Pabellon 1, Ciudad Universitaria, 1428 Buenos Aires, Argentina. ; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany. ; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany. Laboratory for Optical and Computational Instrumentation, University of Wisconsin at Madison, 271 Animal Sciences, 1675 Observatory Drive, Madison, WI 53706, USA. ; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany. Medical Research Council (MRC)-National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK. Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. aoates@nimr.mrc.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25013078" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Body Patterning/*genetics
;
*Doppler Effect
;
Embryo, Nonmammalian/physiology
;
*Periodicity
;
Zebrafish/embryology/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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