Publication Date:
2003-07-19
Description:
In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caspi, Avshalom -- Sugden, Karen -- Moffitt, Terrie E -- Taylor, Alan -- Craig, Ian W -- Harrington, HonaLee -- McClay, Joseph -- Mill, Jonathan -- Martin, Judy -- Braithwaite, Antony -- Poulton, Richie -- MH45070/MH/NIMH NIH HHS/ -- MH49414/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2003 Jul 18;301(5631):386-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, PO80 De Crespigny Park, London, SE5 8AF, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12869766" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
*Alleles
;
Carrier Proteins/*genetics
;
Child
;
Child Abuse
;
Depression/etiology/*genetics
;
Depressive Disorder/etiology/*genetics
;
Disease Susceptibility
;
Female
;
Genetic Predisposition to Disease
;
Heterozygote
;
Homozygote
;
Humans
;
Longitudinal Studies
;
Male
;
Membrane Glycoproteins/*genetics
;
*Membrane Transport Proteins
;
Monoamine Oxidase/genetics
;
*Nerve Tissue Proteins
;
*Polymorphism, Genetic
;
Probability
;
Promoter Regions, Genetic
;
Serotonin Plasma Membrane Transport Proteins
;
Stress, Psychological/*genetics
;
Suicide, Attempted
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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