Publication Date:
1992-06-01
Description:
Self-replicating molecules can be synthesized through the covalent linkage of two complementary subunits to give a self-complementary structure. Complementarity refers to sizes, shapes, and the weak intermolecular forces involved in molecular recognition between the two subunits. In order to provide a model system for evolution at the molecular level, "crossover" or recombination experiments were staged with synthetic replicators. These reactions gave rise to new structural types. The ability (or inability) of the new recombinants to catalyze their own formation is shown to be a consequence of their molecular shapes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feng, Q -- Park, T K -- Rebek, J Jr -- New York, N.Y. -- Science. 1992 May 22;256(5060):1179-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1589798" target="_blank"〉PubMed〈/a〉
Keywords:
Catalysis
;
Ethylamines
;
Hydrogen Bonding
;
*Models, Chemical
;
Molecular Conformation
;
Molecular Structure
;
Thymine
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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