Publication Date:
2006-04-08
Description:
The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lesurtel, Mickael -- Graf, Rolf -- Aleil, Boris -- Walther, Diego J -- Tian, Yinghua -- Jochum, Wolfram -- Gachet, Christian -- Bader, Michael -- Clavien, Pierre-Alain -- New York, N.Y. -- Science. 2006 Apr 7;312(5770):104-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16601191" target="_blank"〉PubMed〈/a〉
Keywords:
5-Hydroxytryptophan/pharmacology
;
Amphetamines/pharmacology
;
Animals
;
Blood Platelets/metabolism/*physiology
;
Busulfan/pharmacology
;
Cell Proliferation
;
Hepatectomy
;
Hepatocytes/cytology
;
Liver/metabolism/*physiology
;
*Liver Regeneration
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Platelet Count
;
Receptor, Serotonin, 5-HT2A/metabolism
;
Receptor, Serotonin, 5-HT2B/metabolism
;
Serotonin/blood/*physiology
;
Serotonin 5-HT2 Receptor Antagonists
;
Thrombocytopenia
;
Ticlopidine/analogs & derivatives/pharmacology
;
Tryptophan Hydroxylase/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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