Publication Date:
2004-01-31
Description:
Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain-enriched tyrosine phosphatase (PEP) in regulating T cell antigen-receptor function during thymocyte development and peripheral T cell differentiation. Although normal naive T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hasegawa, Kiminori -- Martin, Flavius -- Huang, Guangming -- Tumas, Dan -- Diehl, Lauri -- Chan, Andrew C -- New York, N.Y. -- Science. 2004 Jan 30;303(5658):685-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Genentech, Inc., One DNA Way, South San Francisco, CA 94080, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14752163" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autoimmunity
;
B-Lymphocytes/physiology
;
CD4-Positive T-Lymphocytes/immunology/physiology
;
CD8-Positive T-Lymphocytes/immunology/physiology
;
Cell Cycle
;
Gene Targeting
;
Germinal Center/physiology
;
Hydrogen-Ion Concentration
;
Immunoglobulins/blood
;
*Immunologic Memory
;
Lymphocyte Activation
;
Lymphocyte Count
;
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism
;
Mice
;
Mice, Inbred BALB C
;
Mice, Transgenic
;
Phosphorylation
;
Protein Tyrosine Phosphatase, Non-Receptor Type 12
;
Protein Tyrosine Phosphatases/genetics/*metabolism
;
Receptors, Antigen, T-Cell/genetics/immunology
;
Signal Transduction
;
T-Lymphocyte Subsets/immunology
;
T-Lymphocytes/*immunology/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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