Publication Date:
2002-07-06
Description:
Pharmacological inactivation of oncogenes is being investigated as a possible therapeutic strategy for cancer. One potential drawback is that cessation of such therapy may allow reactivation of the oncogene and tumor regrowth. We used a conditional transgenic mouse model for MYC-induced tumorigenesis to demonstrate that brief inactivation of MYC results in the sustained regression of tumors and the differentiation of osteogenic sarcoma cells into mature osteocytes. Subsequent reactivation of MYC did not restore the cells' malignant properties but instead induced apoptosis. Thus, brief MYC inactivation appears to cause epigenetic changes in tumor cells that render them insensitive to MYC-induced tumorigenesis. These results raise the possibility that transient inactivation of MYC may be an effective therapy for certain cancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jain, Meenakshi -- Arvanitis, Constadina -- Chu, Kenneth -- Dewey, William -- Leonhardt, Edith -- Trinh, Maxine -- Sundberg, Christopher D -- Bishop, J Michael -- Felsher, Dean W -- K08-CA75967-01/CA/NCI NIH HHS/ -- R01-CA85610/CA/NCI NIH HHS/ -- R01-CA89305-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):102-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305-5151, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098700" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antineoplastic Agents/administration & dosage/therapeutic use
;
Apoptosis
;
Cell Differentiation
;
Cell Division
;
Doxycycline/pharmacology
;
Gene Expression/drug effects
;
*Gene Silencing
;
*Genes, myc
;
Mice
;
Mice, Transgenic
;
Neoplasm Transplantation
;
Osteocytes/cytology
;
Osteosarcoma/drug therapy/*genetics/*pathology
;
Phenotype
;
Transgenes
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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