Publication Date:
1987-03-20
Description:
The thymidine kinase (tk) promoter of herpes simplex virus includes an octanucleotide sequence motif (ATTTGCAT) that is also an essential component of immunoglobulin kappa gene promoters. In the absence of an enhancer, tk promoter derivatives that contain this element support a higher rate of transcription than those that lack it. The action of the kappa enhancer augments that of the octanucleotide in B lymphoid cells; when both elements are present, tk promoter activity is increased by more than an order of magnitude. In contrast, the presence of the octanucleotide in this promoter markedly reduces its response to a nonimmunoglobulin enhancer. These results suggest that the octanucleotide may mediate a selective interaction among promoters and enhancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parslow, T G -- Jones, S D -- Bond, B -- Yamamoto, K R -- AI22536/AI/NIAID NIH HHS/ -- CA20535/CA/NCI NIH HHS/ -- CM07810/CM/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Mar 20;235(4795):1498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3029871" target="_blank"〉PubMed〈/a〉
Keywords:
DNA, Viral/genetics
;
*Enhancer Elements, Genetic
;
*Gene Expression Regulation
;
*Genes, Regulator
;
Immunoglobulin kappa-Chains/*genetics
;
Lymphocytes/physiology
;
Moloney murine sarcoma virus/genetics
;
*Promoter Regions, Genetic
;
Simplexvirus/genetics
;
Thymidine Kinase/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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