Publikationsdatum:
2015-11-21
Beschreibung:
The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it appears to be absent from other vertebrate species, including birds. To study the evolution and determinants of recombination in species lacking the gene that encodes PRDM9, we inferred fine-scale genetic maps from population resequencing data for two bird species: the zebra finch, Taeniopygia guttata, and the long-tailed finch, Poephila acuticauda. We found that both species have recombination hotspots, which are enriched near functional genomic elements. Unlike in mice and apes, most hotspots are shared between the two species, and their conservation seems to extend over tens of millions of years. These observations suggest that in the absence of PRDM9, recombination targets functional features that both enable access to the genome and constrain its evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Singhal, Sonal -- Leffler, Ellen M -- Sannareddy, Keerthi -- Turner, Isaac -- Venn, Oliver -- Hooper, Daniel M -- Strand, Alva I -- Li, Qiye -- Raney, Brian -- Balakrishnan, Christopher N -- Griffith, Simon C -- McVean, Gil -- Przeworski, Molly -- 086786/Z/08/Z/Wellcome Trust/United Kingdom -- 090532/Z/09/Z/Wellcome Trust/United Kingdom -- 100956/Wellcome Trust/United Kingdom -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2015 Nov 20;350(6263):928-32. doi: 10.1126/science.aad0843.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Department of Systems Biology, Columbia University, New York, NY 10032, USA. sonal.singhal1@gmail.com molly.przew@gmail.com. ; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. ; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. ; Committee on Evolutionary Biology, University of Chicago, Chicago, IL 60637, USA. ; Department of Biological Sciences, Columbia University, New York, NY 10027, USA. ; China National Genebank, BGI-Shenzhen, Shenzhen 518083, China. ; Center for Biomolecular Science and Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA. ; Department of Biology, East Carolina University, Greenville, NC 27858, USA. ; Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26586757" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Chromosome Mapping
;
*Evolution, Molecular
;
Finches/*genetics
;
*Gene Expression Regulation
;
Genome
;
*Recombination, Genetic
;
Repressor Proteins/*genetics
;
Species Specificity
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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