Publication Date:
2006-10-14
Description:
Riboswitches are structured RNAs typically located in the 5' untranslated regions of bacterial mRNAs that bind metabolites and control gene expression. Most riboswitches sense one metabolite and function as simple genetic switches. However, we found that the 5' region of the Bacillus clausii metE messenger RNA includes two riboswitches that respond to S-adenosylmethionine and coenzyme B12. This tandem arrangement yields a composite gene control system that functions as a two-input Boolean NOR logic gate. These findings and the discovery of additional tandem riboswitch architectures reveal how simple RNA elements can be assembled to make sophisticated genetic decisions without involving protein factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sudarsan, Narasimhan -- Hammond, Ming C -- Block, Kirsten F -- Welz, Rudiger -- Barrick, Jeffrey E -- Roth, Adam -- Breaker, Ronald R -- GM 068819/GM/NIGMS NIH HHS/ -- GM 07223-31/GM/NIGMS NIH HHS/ -- R01 GM068819/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Oct 13;314(5797):300-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520-8103, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17038623" target="_blank"〉PubMed〈/a〉
Keywords:
5' Untranslated Regions/*metabolism
;
Aptamers, Nucleotide/chemistry/metabolism
;
Bacillus/*genetics/growth & development/metabolism
;
Base Sequence
;
Cobamides/*metabolism/pharmacology
;
*Gene Expression Regulation, Bacterial
;
Genes, Bacterial
;
Ligands
;
Methionine/biosynthesis/pharmacology
;
Molecular Sequence Data
;
Nucleic Acid Conformation
;
RNA, Bacterial/chemistry/genetics/metabolism
;
RNA, Messenger/chemistry/genetics/metabolism
;
S-Adenosylmethionine/*metabolism
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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