Publication Date:
2000-10-14
Description:
Model organisms such as yeast have proved exceptionally valuable for revealing new information about the molecular pathways involved in the aging of cells. In her Perspective, Campisi comments on new work showing that caloric restriction increases longevity in yeast by activating the SIR2 gene, which alters the compactness of chromatin and thus regulates gene expression (Lin et al.).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campisi, J -- New York, N.Y. -- Science. 2000 Sep 22;289(5487):2062-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. jcampisi@lbl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11032557" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/*physiology
;
Animals
;
Cell Division
;
Chromatin/*physiology
;
DNA Repair
;
DNA Replication
;
DNA, Circular/metabolism
;
DNA, Fungal/metabolism
;
DNA, Ribosomal/metabolism
;
*Energy Intake
;
*Gene Silencing
;
Glucose/metabolism
;
Histone Deacetylases/genetics/*metabolism
;
Histones/metabolism
;
Longevity
;
Mutation
;
NAD/metabolism
;
Reactive Oxygen Species/metabolism
;
Recombination, Genetic
;
Saccharomyces cerevisiae/genetics/*physiology
;
*Silent Information Regulator Proteins, Saccharomyces cerevisiae
;
Sirtuin 2
;
Sirtuins
;
Trans-Activators/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
