Publication Date:
2001-07-14
Description:
The immune system is capable of making qualitatively distinct responses against different microbial infections, and recent advances are starting to reveal how it manages this complex task. An integral component of the immune system is a network of cells known as dendritic cells (DCs), which sense different microbial stimuli and convey this information to lymphocytes. A better understanding of DC biology has allowed a model to be constructed in which the type of immune response to an infection is viewed as a function of several determinants, including the subpopulation of DCs, the nature of the microbe, microbe recognition receptors, and the cytokine microenvironment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pulendran, B -- Palucka, K -- Banchereau, J -- 1R21AI/DE48154-01/AI/NIAID NIH HHS/ -- AI48638-01/AI/NIAID NIH HHS/ -- DK 57665-01/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2001 Jul 13;293(5528):253-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA. balip@baylordallas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11452116" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bacteria/immunology
;
Cytokines/immunology
;
Dendritic Cells/classification/*immunology
;
*Drosophila Proteins
;
Eukaryota/immunology
;
Fungi/immunology
;
Humans
;
*Immunity
;
Immunotherapy
;
Membrane Glycoproteins/immunology
;
Receptors, Cell Surface/immunology
;
Toll-Like Receptors
;
Viruses/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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