Publication Date:
2002-03-30
Description:
To begin to understand the genetic architecture of natural variation in gene expression, we carried out genetic linkage analysis of genomewide expression patterns in a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae. Over 1500 genes were differentially expressed between the parent strains. Expression levels of 570 genes were linked to one or more different loci, with most expression levels showing complex inheritance patterns. The loci detected by linkage fell largely into two categories: cis-acting modulators of single genes and trans-acting modulators of many genes. We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brem, Rachel B -- Yvert, Gael -- Clinton, Rebecca -- Kruglyak, Leonid -- GM64268/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):752-5. Epub 2002 Mar 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fred Hutchinson Cancer Research Center (FHCRC), 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA and Howard Hughes Medical Institute.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11923494" target="_blank"〉PubMed〈/a〉
Keywords:
Chromosome Mapping
;
Crosses, Genetic
;
*DNA-Binding Proteins
;
Fungal Proteins/genetics/metabolism
;
Gene Expression Profiling
;
*Gene Expression Regulation, Fungal
;
Genes, Fungal
;
Genetic Linkage
;
Genetic Markers
;
Genome, Fungal
;
Genotype
;
Oligonucleotide Array Sequence Analysis
;
Polymorphism, Genetic
;
RNA, Fungal/genetics/metabolism
;
RNA, Messenger/genetics/metabolism
;
Regulatory Sequences, Nucleic Acid
;
Saccharomyces cerevisiae/*genetics/growth & development/physiology
;
Saccharomyces cerevisiae Proteins/genetics/metabolism
;
Trans-Activators/genetics/metabolism
;
Transcription Factors/genetics/metabolism
;
*Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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