Publication Date:
2006-01-21
Description:
Structural genomics (SG) projects aim to expand our structural knowledge of biological macromolecules while lowering the average costs of structure determination. We quantitatively analyzed the novelty, cost, and impact of structures solved by SG centers, and we contrast these results with traditional structural biology. The first structure identified in a protein family enables inference of the fold and of ancient relationships to other proteins; in the year ending 31 January 2005, about half of such structures were solved at a SG center rather than in a traditional laboratory. Furthermore, the cost of solving a structure at the most efficient SG center in the United States has dropped to one-quarter of the estimated cost of solving a structure by traditional methods. However, the efficiency of the top structural biology laboratories-even though they work on very challenging structures-is comparable to that of SG centers; moreover, traditional structural biology papers are cited significantly more often, suggesting greater current impact.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chandonia, John-Marc -- Brenner, Steven E -- 1-K22-HG00056/HG/NHGRI NIH HHS/ -- 1-P50-GM62412/GM/NIGMS NIH HHS/ -- 1-R01-GM073109/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Jan 20;311(5759):347-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Berkeley Structural Genomics Center, Physical Biosciences Division, Lawrence Berkeley National Laboratory, and Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16424331" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
*Computational Biology
;
Costs and Cost Analysis
;
Databases, Protein
;
Financial Support
;
*Genomics/economics
;
*Protein Conformation
;
Protein Folding
;
Proteins/*chemistry/classification
;
Publishing
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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