Publication Date:
1984-03-09
Description:
The complete amino acid sequence of rat transforming growth factor type 1 has been determined. This growth factor, obtained from retrovirus-transformed fibroblasts, is structurally and functionally related to mouse epidermal growth factor and human urogastrone. Production of this polypeptide by various neoplastic cells might contribute to the continued expression of the transformed phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marquardt, H -- Hunkapiller, M W -- Hood, L E -- Todaro, G J -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1079-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6320373" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Cell Line
;
*Cell Transformation, Neoplastic
;
DNA/biosynthesis
;
Epidermal Growth Factor/*metabolism/pharmacology
;
Humans
;
Idoxuridine/metabolism
;
Mice
;
Peptide Biosynthesis
;
Peptides/*metabolism/pharmacology
;
Rats
;
Receptor, Epidermal Growth Factor
;
Receptors, Cell Surface/metabolism
;
Structure-Activity Relationship
;
Transforming Growth Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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