Publication Date:
2010-11-26
Description:
In bacteria, the rate of cell proliferation and the level of gene expression are intimately intertwined. Elucidating these relations is important both for understanding the physiological functions of endogenous genetic circuits and for designing robust synthetic systems. We describe a phenomenological study that reveals intrinsic constraints governing the allocation of resources toward protein synthesis and other aspects of cell growth. A theory incorporating these constraints can accurately predict how cell proliferation and gene expression affect one another, quantitatively accounting for the effect of translation-inhibiting antibiotics on gene expression and the effect of gratuitous protein expression on cell growth. The use of such empirical relations, analogous to phenomenological laws, may facilitate our understanding and manipulation of complex biological systems before underlying regulatory circuits are elucidated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scott, Matthew -- Gunderson, Carl W -- Mateescu, Eduard M -- Zhang, Zhongge -- Hwa, Terence -- R01GM77298/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Nov 19;330(6007):1099-102. doi: 10.1126/science.1192588.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Theoretical Biological Physics, Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21097934" target="_blank"〉PubMed〈/a〉
Keywords:
*Cell Proliferation
;
Escherichia coli K12/*genetics/*growth & development
;
Escherichia coli Proteins/genetics
;
Gene Expression/*physiology
;
Models, Biological
;
Protein Biosynthesis
;
RNA, Bacterial/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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