Publication Date:
2006-10-07
Description:
Although class I myosins are known to play a wide range of roles, the physiological function of long-tailed class I myosins in vertebrates remains elusive. We demonstrated that one of these proteins, Myo1f, is expressed predominantly in the mammalian immune system. Cells from Myo1f-deficient mice exhibited abnormally increased adhesion and reduced motility, resulting from augmented exocytosis of beta2 integrin-containing granules. Also, the cortical actin that co-localizes with Myo1f was reduced in Myo1f-deficient cells. In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Myo1f directs immune cell motility and innate host defense against infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Sangwon V -- Mehal, Wajahat Z -- Dong, Xuemei -- Heinrich, Volkmar -- Pypaert, Marc -- Mellman, Ira -- Dembo, Micah -- Mooseker, Mark S -- Wu, Dianqing -- Flavell, Richard A -- K08 DK02965/DK/NIDDK NIH HHS/ -- R01 DK25387/DK/NIDDK NIH HHS/ -- R01 GM054597/GM/NIGMS NIH HHS/ -- R01 GM073823/GM/NIGMS NIH HHS/ -- R01 GM72002/GM/NIGMS NIH HHS/ -- R01 HL080706/HL/NHLBI NIH HHS/ -- R01 HL080706-10/HL/NHLBI NIH HHS/ -- R01 HL080706-11/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2006 Oct 6;314(5796):136-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17023661" target="_blank"〉PubMed〈/a〉
Keywords:
Actins/metabolism
;
Animals
;
Antigens, CD18/metabolism
;
*Cell Adhesion
;
Cell Degranulation
;
*Cell Movement
;
Chemotaxis, Leukocyte
;
Colony Count, Microbial
;
Cytoplasmic Granules/metabolism
;
Exocytosis
;
*Immunity, Innate
;
Ligands
;
Listeria monocytogenes/growth & development
;
Listeriosis/*immunology/microbiology
;
Mice
;
Mice, Knockout
;
Myosin Type I/deficiency/genetics/*physiology
;
N-Formylmethionine Leucyl-Phenylalanine
;
Neutrophil Activation
;
Neutrophils/immunology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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