Publikationsdatum:
2007-10-27
Beschreibung:
Addiction profoundly alters motivational circuits so that drugs become powerful reinforcers of behavior. The interoceptive system continuously updates homeostatic and emotional information that are important elements in motivational decisions. We tested the idea that interoceptive information is essential in drug craving and in the behavioral signs of malaise. We inactivated the primary interoceptive cortex in amphetamine-experienced rats, which prevented the urge to seek amphetamine in a place preference task. Interoceptive insula inactivation also blunted the signs of malaise induced by acute lithium administration. Drug-seeking and malaise both induced Fos expression, a marker of neuronal activation, in the insula. We conclude that the insular cortex is a key structure in the perception of bodily needs that provides direction to motivated behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Contreras, Marco -- Ceric, Francisco -- Torrealba, Fernando -- New York, N.Y. -- Science. 2007 Oct 26;318(5850):655-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17962567" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Amphetamine-Related Disorders/*physiopathology
;
Animals
;
*Behavior, Addictive
;
*Behavior, Animal/drug effects
;
Cerebral Cortex/*physiology/physiopathology
;
Conditioning (Psychology)
;
Dextroamphetamine/administration & dosage
;
Fatigue/*chemically induced
;
Lidocaine/administration & dosage/pharmacology
;
Lithium Chloride/administration & dosage/*pharmacology
;
Male
;
Motor Activity/*drug effects
;
Rats
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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