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  • 1
    Publication Date: 2011-10-15
    Description: Intestinal bacteria aid host health and limit bacterial pathogen colonization. However, the influence of bacteria on enteric viruses is largely unknown. We depleted the intestinal microbiota of mice with antibiotics before inoculation with poliovirus, an enteric virus. Antibiotic-treated mice were less susceptible to poliovirus disease and supported minimal viral replication in the intestine. Exposure to bacteria or their N-acetylglucosamine-containing surface polysaccharides, including lipopolysaccharide and peptidoglycan, enhanced poliovirus infectivity. We found that poliovirus binds lipopolysaccharide, and exposure of poliovirus to bacteria enhanced host cell association and infection. The pathogenesis of reovirus, an unrelated enteric virus, also was more severe in the presence of intestinal microbes. These results suggest that antibiotic-mediated microbiota depletion diminishes enteric virus infection and that enteric viruses exploit intestinal microbes for replication and transmission.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222156/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222156/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuss, Sharon K -- Best, Gavin T -- Etheredge, Chris A -- Pruijssers, Andrea J -- Frierson, Johnna M -- Hooper, Lora V -- Dermody, Terence S -- Pfeiffer, Julie K -- AI38296/AI/NIAID NIH HHS/ -- F32 NS071986/NS/NINDS NIH HHS/ -- P30 CA68485/CA/NCI NIH HHS/ -- P60 DK20593/DK/NIDDK NIH HHS/ -- R01 AI074668/AI/NIAID NIH HHS/ -- R01 AI074668-04/AI/NIAID NIH HHS/ -- R01 AI74668/AI/NIAID NIH HHS/ -- R01 DK070855/DK/NIDDK NIH HHS/ -- R01 DK070855-06/DK/NIDDK NIH HHS/ -- T32 AI007520/AI/NIAID NIH HHS/ -- T32 AI07611/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Oct 14;334(6053):249-52. doi: 10.1126/science.1211057.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21998395" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/pharmacology ; *Bacterial Physiological Phenomena ; Cells, Cultured ; Feces/microbiology/virology ; HeLa Cells ; Humans ; Intestines/*microbiology/virology ; Lipopolysaccharides/metabolism ; Mammalian orthoreovirus 3/*physiology ; *Metagenome ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Poliomyelitis/*virology ; Poliovirus/metabolism/pathogenicity/*physiology ; Reoviridae Infections/*virology ; *Virus Replication ; Virus Shedding
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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