Publication Date:
2003-09-13
Description:
Stem cell self-renewal can be specified by local signals from the surrounding microenvironment, or niche. However, the relation between the niche and the mechanisms that ensure the correct balance between stem cell self-renewal and differentiation is poorly understood. Here, we show that dividing Drosophila male germline stem cells use intracellular mechanisms involving centrosome function and cortically localized Adenomatous Polyposis Coli tumor suppressor protein to orient mitotic spindles perpendicular to the niche, ensuring a reliably asymmetric outcome in which one daughter cell remains in the niche and self-renews stem cell identity, whereas the other, displaced away, initiates differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamashita, Yukiko M -- Jones, D Leanne -- Fuller, Margaret T -- 1P01 DK53074/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2003 Sep 12;301(5639):1547-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12970569" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Arabidopsis Proteins
;
Cadherins/metabolism
;
Calcium-Binding Proteins/*metabolism
;
Cell Count
;
Cell Differentiation
;
*Cell Division
;
Cell Polarity
;
Centrosome/*physiology
;
Cytoskeletal Proteins/metabolism
;
Drosophila/*cytology/genetics/physiology
;
Drosophila Proteins/*metabolism
;
Germ Cells/cytology/*physiology
;
Homeodomain Proteins/genetics/physiology
;
Male
;
Mutation
;
Spindle Apparatus/physiology
;
Stem Cells/cytology/*physiology
;
Testis/cytology
;
Trans-Activators/metabolism
;
Tubulin/metabolism
;
Tumor Suppressor Proteins/*metabolism
;
beta Catenin
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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