Publication Date:
1993-12-24
Description:
Major histocompatibility complex (MHC) class I molecules associate with peptides that are delivered from the cytosol to the lumen of the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Liver microsomes of SHR and Lewis rats, which express different alleles of TAP (cim(b) and cim(a), respectively), accumulate different sets of peptides. Use of MHC congenic rats assigned this difference to the MHC, independent of the class I products expressed. Both the cim(a) and cim(b) TAP complexes translocate peptides with a hydrophobic carboxyl terminus, but translocation of peptides with a carboxyl-terminal His, Lys, or Arg residue is unique to cim(a). Thus, the specificity of the TAP peptide translocator restricts the peptides available for antigen presentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heemels, M T -- Schumacher, T N -- Wonigeit, K -- Ploegh, H L -- R01 AI3 3456-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 24;262(5142):2059-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266106" target="_blank"〉PubMed〈/a〉
Keywords:
*ATP-Binding Cassette Transporters
;
Alleles
;
Amino Acid Sequence
;
Animals
;
Antigen Presentation/*physiology
;
Biological Transport/physiology
;
Carrier Proteins/genetics/*physiology
;
Histocompatibility Antigens Class I/physiology
;
Histocompatibility Antigens Class II/genetics/*physiology
;
In Vitro Techniques
;
Microsomes, Liver/metabolism
;
Molecular Sequence Data
;
Oligopeptides/*metabolism
;
Rats
;
Rats, Inbred BN
;
Rats, Inbred Lew
;
Rats, Inbred SHR
;
Substrate Specificity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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