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NMR investigation of the interaction of (+)- and (-)-flurbiprofen with β-cyclodextrin (1996)

Salvadori, Piero ; Uccello-Barretta, Gloria ; Balzano, Federica ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Chirality 8 (1996), S. 423-429

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ISSN: 0899-0042

Keywords: flurbiprofen ; β-cyclodextrin ; chiral discrimination ; nuclear magnetic resonance ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The sodium salts of (+)-(S)- and (-)-(R)-2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen, FBP) form 1:1 inclusion complexes with β-cyclodextrin (β-CD) having different association constants. Proton selective relaxation rate measurements revealed the existence of superior aggregated forms for both complexes (+)-FBP/β-CD and (-)-FBP/β-CD; information about their stereochemistry has been obtained by 2D ROESY analysis. © 1996 Wiley-Liss, Inc.

Additional Material: 7 Ill.

Type of Medium: Electronic Resource

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