Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The development of a new method for the intramolecular coupling of terminal alkynes and for the synthesis of seven- and eight-membered benzoheterocycles is reported. The key steps involve the generation of zirconocene-alkyne complexes from 2-bromoalkenes and the subsequent intramolecular carbometalation of olefins or acetylides. The 8-unsubstituted zirconabicyclopentenes were carbonylated to afford unexpected products and allow access to polyfunctionalized molecules from simple starting materials.
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