Double bond migration
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
---Treatment of 3-alkylidene or 3-benzylidene-2,5-piperazinediones 6 with catalytic amounts of acid gives rise to the formation of isomers 7 by migration of the C=C bond into the alkyl substituent at position 6, or results in mixtures of racemic 7 and E isomers 8. The existence of tautomeric equilibria is discussed.
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