ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Humans  (33)
  • American Association for the Advancement of Science (AAAS)  (33)
  • Wiley
  • 1
    Publication Date: 2007-09-18
    Description: Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe a novel posttranslational modification that leads to anti-inflammatory activity of antibodies of immunoglobulin G, isotype 4 (IgG4). IgG4 antibodies are dynamic molecules that exchange Fab arms by swapping a heavy chain and attached light chain (half-molecule) with a heavy-light chain pair from another molecule, which results in bispecific antibodies. Mutagenesis studies revealed that the third constant domain is critical for this activity. The impact of IgG4 Fab arm exchange was confirmed in vivo in a rhesus monkey model with experimental autoimmune myasthenia gravis. IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van der Neut Kolfschoten, Marijn -- Schuurman, Janine -- Losen, Mario -- Bleeker, Wim K -- Martinez-Martinez, Pilar -- Vermeulen, Ellen -- den Bleker, Tamara H -- Wiegman, Luus -- Vink, Tom -- Aarden, Lucien A -- De Baets, Marc H -- van de Winkel, Jan G J -- Aalberse, Rob C -- Parren, Paul W H I -- New York, N.Y. -- Science. 2007 Sep 14;317(5844):1554-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sanquin Research-AMC Landsteiner Laboratory, Department of Immunopathology, Plesmanlaan 125, 1066 CX Amsterdam, the Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17872445" target="_blank"〉PubMed〈/a〉
    Keywords: Allergens/immunology ; Animals ; Antibodies, Bispecific/immunology ; Antibodies, Monoclonal/immunology ; Antigens, CD20/immunology ; Antigens, Plant ; Autoantibodies/immunology ; Glycoproteins/immunology ; Humans ; Immunoglobulin Constant Regions/chemistry ; Immunoglobulin Fab Fragments/*chemistry/*immunology/metabolism ; Immunoglobulin G/*chemistry/*immunology/metabolism ; Immunoglobulin Heavy Chains ; Macaca mulatta ; Mice ; Mutation ; Myasthenia Gravis, Autoimmune, Experimental/immunology/prevention & control ; Protein Processing, Post-Translational ; Receptor, Epidermal Growth Factor/immunology ; Receptors, Cholinergic/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2003-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rajagopal, Jayaraj -- Anderson, William J -- Kume, Shoen -- Martinez, Olga I -- Melton, Douglas A -- New York, N.Y. -- Science. 2003 Jan 17;299(5605):363.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12532008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/immunology ; Apoptosis ; Cell Differentiation ; Cell Line ; Embryo, Mammalian/*cytology ; Humans ; Insulin/*analysis/genetics/immunology/*metabolism ; Islets of Langerhans/*cytology/metabolism ; Mice ; Microscopy, Confocal ; RNA, Messenger/genetics/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Stem Cells/*cytology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2004-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmer, Margaret -- Bernhardt, Emily -- Chornesky, Elizabeth -- Collins, Scott -- Dobson, Andrew -- Duke, Clifford -- Gold, Barry -- Jacobson, Robert -- Kingsland, Sharon -- Kranz, Rhonda -- Mappin, Michael -- Martinez, M Luisa -- Micheli, Fiorenza -- Morse, Jennifer -- Pace, Michael -- Pascual, Mercedes -- Palumbi, Stephen -- Reichman, O J -- Simons, Ashley -- Townsend, Alan -- Turner, Monica -- New York, N.Y. -- Science. 2004 May 28;304(5675):1251-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Maryland, College Park, MD, USA. mpalmer@umd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15166349" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Communicable Diseases/transmission ; Conservation of Natural Resources ; *Ecology ; *Ecosystem ; Environment ; Forecasting ; Fresh Water ; Health ; Human Activities ; Humans ; Population Dynamics ; *Research ; Urbanization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2005-07-16
    Description: Gross inequities in disease burden between developed and developing countries are now the subject of intense global attention. Public and private donors have marshaled resources and created organizational structures to accelerate the development of new health products and to procure and distribute drugs and vaccines for the poor. Despite these encouraging efforts directed primarily from and funded by industrialized countries, sufficiency and sustainability remain enormous challenges because of the sheer magnitude of the problem. Here we highlight a complementary and increasingly important means to improve health equity: the growing ability of some developing countries to undertake health innovation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morel, Carlos M -- Acharya, Tara -- Broun, Denis -- Dangi, Ajit -- Elias, Christopher -- Ganguly, N K -- Gardner, Charles A -- Gupta, R K -- Haycock, Jane -- Heher, Anthony D -- Hotez, Peter J -- Kettler, Hannah E -- Keusch, Gerald T -- Krattiger, Anatole F -- Kreutz, Fernando T -- Lall, Sanjaya -- Lee, Keun -- Mahoney, Richard -- Martinez-Palomo, Adolfo -- Mashelkar, R A -- Matlin, Stephen A -- Mzimba, Mandi -- Oehler, Joachim -- Ridley, Robert G -- Senanayake, Pramilla -- Singer, Peter -- Yun, Mikyung -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):401-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Technological Development in Health, Oswaldo Cruz Foundation (FIOCRUZ), Avenida Brasil 4365, Rio de Janeiro, RJ 21040-900, Brazil. morel@fiocruz.br〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020723" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research/economics ; Biotechnology ; *Delivery of Health Care/organization & administration ; Developed Countries ; *Developing Countries ; *Diffusion of Innovation ; Drug Industry ; Health Policy ; Humans ; International Cooperation ; Patents as Topic ; Private Sector ; Public Sector ; Publishing ; Technology Transfer
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2006-09-16
    Description: A block with a hitherto unknown system of writing has been found in the Olmec heartland of Veracruz, Mexico. Stylistic and other dating of the block places it in the early first millennium before the common era, the oldest writing in the New World, with features that firmly assign this pivotal development to the Olmec civilization of Mesoamerica.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rodriguez Martinez, Ma del Carmen -- Ortiz Ceballos, Ponciano -- Coe, Michael D -- Diehl, Richard A -- Houston, Stephen D -- Taube, Karl A -- Delgado Calderon, Alfredo -- New York, N.Y. -- Science. 2006 Sep 15;313(5793):1610-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centro del Instituto Nacional de Antropologia e Historia, Benito Juarez Numero 425-431, Veracruz, Mexico.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16973873" target="_blank"〉PubMed〈/a〉
    Keywords: *Archaeology ; Civilization/*history ; *Culture ; History, Ancient ; Humans ; Mexico ; Writing/*history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2011-06-02
    Description: The retrovirus XMRV (xenotropic murine leukemia virus-related virus) has been detected in human prostate tumors and in blood samples from patients with chronic fatigue syndrome, but these findings have not been replicated. We hypothesized that an understanding of when and how XMRV first arose might help explain the discrepant results. We studied human prostate cancer cell lines CWR22Rv1 and CWR-R1, which produce XMRV virtually identical to the viruses recently found in patient samples, as well as their progenitor human prostate tumor xenograft (CWR22) that had been passaged in mice. We detected XMRV infection in the two cell lines and in the later passage xenografts, but not in the early passages. In particular, we found that the host mice contained two proviruses, PreXMRV-1 and PreXMRV-2, which share 99.92% identity with XMRV over 〉3.2-kilobase stretches of their genomes. We conclude that XMRV was not present in the original CWR22 tumor but was generated by recombination of two proviruses during tumor passaging in mice. The probability that an identical recombinant was generated independently is negligible (~10(-12)); our results suggest that the association of XMRV with human disease is due to contamination of human samples with virus originating from this recombination event.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278917/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278917/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paprotka, Tobias -- Delviks-Frankenberry, Krista A -- Cingoz, Oya -- Martinez, Anthony -- Kung, Hsing-Jien -- Tepper, Clifford G -- Hu, Wei-Shau -- Fivash, Matthew J Jr -- Coffin, John M -- Pathak, Vinay K -- P30 CA093373/CA/NCI NIH HHS/ -- R01CA150197/CA/NCI NIH HHS/ -- R37 CA 089441/CA/NCI NIH HHS/ -- R37 CA089441/CA/NCI NIH HHS/ -- R37 CA089441-11/CA/NCI NIH HHS/ -- ZIA BC011339-02/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):97-101. doi: 10.1126/science.1205292. Epub 2011 May 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21628392" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Tumor/*virology ; DNA Contamination ; DNA, Viral/analysis ; Endogenous Retroviruses/genetics ; Fatigue Syndrome, Chronic/virology ; Gammaretrovirus/*genetics ; Genes, env ; Genes, gag ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Polymerase Chain Reaction ; Prostatic Neoplasms/*virology ; Proviruses/genetics/isolation & purification ; *Recombination, Genetic ; Transplantation, Heterologous ; Xenotropic murine leukemia virus-related virus/*genetics/*isolation & ; purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2001-11-10
    Description: The internal organization of a higher level visual area in the human parietal cortex was mapped. Functional magnetic resonance images were acquired while the polar angle of a peripheral target for a delayed saccade was gradually changed. A region in the superior parietal cortex showed robust retinotopic mapping of the remembered target angle. The map reversed when the direction of rotation of the remembered targets was reversed and persisted unchanged when study participants detected rare target reappearances while maintaining fixation, or when the eccentricity of successive remembered targets was unpredictable. This region may correspond to the lateral intraparietal area in macaque monkeys.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sereno, M I -- Pitzalis, S -- Martinez, A -- MH25594/MH/NIMH NIH HHS/ -- NICHD22614/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2001 Nov 9;294(5545):1350-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cognitive Science, Department of Radiology, University of California, San Diego, La Jolla, CA 92093-0515, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11701930" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Mapping ; Echo-Planar Imaging ; Fixation, Ocular ; Humans ; Magnetic Resonance Imaging ; Memory/physiology ; Parietal Lobe/anatomy & histology/*physiology ; Saccades/*physiology ; Visual Cortex/physiology ; Visual Pathways/*physiology ; *Visual Perception
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2001-10-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, J A -- Weisell, R -- Chevassus, S -- Martinez, C D -- Burlingame, B -- Coward, W A -- DK 56650/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):812.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology, Department of Internal Medicine, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA. levine.james@mayo.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679660" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Cote d'Ivoire ; Female ; Humans ; Leisure Activities ; Male ; Nutritional Physiological Phenomena ; Rural Population ; Sex Characteristics ; Sleep ; *Women, Working ; *Work
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    facet.materialart.
    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, James A -- Weisell, Robert -- Chevassus, Simon -- Martinez, Claudio D -- Burlingame, Barbara -- New York, N.Y. -- Science. 2002 May 10;296(5570):1025-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004902" target="_blank"〉PubMed〈/a〉
    Keywords: Activities of Daily Living ; Adolescent ; Adult ; Child ; *Child Welfare ; Cote d'Ivoire ; Education ; *Employment ; Female ; Humans ; Leisure Activities ; Male ; Poverty ; Sex Characteristics ; Sleep
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2002-12-10
    Description: We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for comprehensive analysis of protein phosphorylation in normal and disease states, as well as a detailed view of the current state of human genome analysis through a focus on one large gene family. We identify 518 putative protein kinase genes, of which 71 have not previously been reported or described as kinases, and we extend or correct the protein sequences of 56 more kinases. New genes include members of well-studied families as well as previously unidentified families, some of which are conserved in model organisms. Classification and comparison with model organism kinomes identified orthologous groups and highlighted expansions specific to human and other lineages. We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manning, G -- Whyte, D B -- Martinez, R -- Hunter, T -- Sudarsanam, S -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1912-34.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉SUGEN Inc., 230 East Grand Avenue, South San Francisco, CA 94080, USA. gerard-manning@sugen.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471243" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catalysis ; Chromosome Mapping ; Computational Biology ; Databases, Genetic ; Genes ; *Genome, Human ; Humans ; Neoplasms/genetics ; Phylogeny ; Protein Kinases/chemistry/classification/*genetics/*metabolism ; Protein Structure, Tertiary ; Pseudogenes ; Sequence Analysis, DNA ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...