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  • 1
    Publication Date: 1980-01-11
    Description: Stereoisomers of the barbiturate anesthetic pentobarbital were applied to mouse spinal neurons growing in tissue culture. Intracellular recordings of neuronal membrane properties revealed that the (+) and (-) isomers caused direct changes in membrane potential and conductance on some but not all of the cells tested. The action of the (+) isomer was predominantly excitatory, whereas the (-) isomer produced predominantly inhibitory responses. The (-) isomer was considerably more effective in potentiating inhibitory responses to the transmitter gamma-aminobutyric acid. The results show that pentobarbital has multiple effects on neuronal excitability and demonstrate the presence of stereospecific sites of barbiturate action on central neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, L Y -- Barker, J L -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350656" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Electric Conductivity ; Membrane Potentials/drug effects ; Mice ; Neural Inhibition/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Spinal Cord/embryology ; Stereoisomerism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1978-05-19
    Description: Barbiturate anesthetics, but not anticonvulsants, abolish the spontaneous activity of cultured spinal cord neurons; directly increase membrane conductance, an effect which is suppressed by the gamma-aminobutyric acid (GABA) antagonists picrotoxin and penicillin; and are more potent than anticonvulsants in augmenting GABA and depressing glutamate responses. Barbiturate anticonvulsants abolish picrotoxin-induced convulsive activity. These results indicate qualitative and quantitative differences between anesthetic and anticonvulsant barbiturates, which may explain their different clinical effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macdonald, R L -- Barker, J L -- New York, N.Y. -- Science. 1978 May 19;200(4343):775-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205953" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cells, Cultured ; Electric Conductivity ; Glutamates/pharmacology ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Pentobarbital/*pharmacology ; Phenobarbital/*pharmacology ; Picrotoxin/pharmacology ; Receptors, Neurotransmitter/drug effects ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1979-08-17
    Description: Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacDonald, J F -- Barker, J L -- Paul, S M -- Marangos, P J -- Skolnick, P -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):715-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/37602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Cells, Cultured ; Electric Conductivity ; Flurazepam/antagonists & inhibitors ; Inosine/*metabolism/pharmacology ; Ligands ; Mice ; Neurotransmitter Agents/metabolism ; Receptors, Drug/*metabolism ; Receptors, Neurotransmitter/metabolism ; Spinal Cord/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2019-07-13
    Description: A general overview of the LANDSAT 4 system with emphasis on the Thematic Mapper (TM) is presented. A variety of topics on the design, calibration, capabilities, and image processing techniques of the TM sensor are discussed in detail. The comparison of TM data with other MSS data is also investigated.
    Keywords: GEOSCIENCES (GENERAL)
    Type: E84-10166 , NASA-CP-2326-VOL-1 , NAS 1.55:2326-VOL-1 , Proc. of LANDSAT-4 Early Results Symp.; 22-24 Feb. 1983; Greenbelt, MD; United States|LANDSAT Sci. Characterization Workshop; 6 Dec. 1983
    Format: application/pdf
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  • 6
    Publication Date: 2019-07-13
    Description: A series of brief summaries of the results of individual investigations of LANDSAT 4 image data characteristics are presented. Topics are divided into MSS and TM investigations, and applications of the imaging techniques. Radiometric and geometric accuracy are emphasized.
    Keywords: GEOSCIENCES (GENERAL)
    Type: E84-10167 , NASA-CP-2326-VOL-2 , NAS 1.55:2326-VOL-2 , LANDSAT-4 Early Results Symposium; 22-24 Feb. 1983; Greenbelt, MD; United States
    Format: application/pdf
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