On-line coupled LC-GC
Mixing in the sample loop
Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
During introduction of an LC fraction into the sample loop of the loop-type interface mixing occurs between the fraction of interest and the material previously eluted from the LC. Such mixing may not only result in losses of the solute material of interest, but also in contamination of the fraction of interest with material from which it was supposed to have been isolated. Experimental determination of the extent of mixing has led to the conclusion that whereas the effects are negligible under some conditions, in some circumstances the mixing can cause severe problems.
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