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  • 1
    Publication Date: 2000-08-26
    Description: Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not in carcinomas, the most common human cancers. Here, we report that t(2;3)(q13;p25), a translocation identified in a subset of human thyroid follicular carcinomas, results in fusion of the DNA binding domains of the thyroid transcription factor PAX8 to domains A to F of the peroxisome proliferator-activated receptor (PPAR) gamma1. PAX8-PPARgamma1 mRNA and protein were detected in 5 of 8 thyroid follicular carcinomas but not in 20 follicular adenomas, 10 papillary carcinomas, or 10 multinodular hyperplasias. PAX8-PPARgamma1 inhibited thiazolidinedione-induced transactivation by PPARgamma1 in a dominant negative manner. The experiments demonstrate an oncogenic role for PPARgamma and suggest that PAX8-PPARgamma1 may be useful in the diagnosis and treatment of thyroid carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kroll, T G -- Sarraf, P -- Pecciarini, L -- Chen, C J -- Mueller, E -- Spiegelman, B M -- Fletcher, J A -- CA75425/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2000 Aug 25;289(5483):1357-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma, Follicular/*genetics/metabolism ; Adenoma/genetics/metabolism ; Adult ; Aged ; Carcinoma, Papillary/genetics/metabolism ; Cell Line ; Cell Nucleus/metabolism ; Child ; DNA-Binding Proteins/chemistry/genetics/pharmacology/*physiology ; Humans ; Middle Aged ; *Nuclear Proteins ; Oncogene Proteins, Fusion/chemistry/genetics/*physiology ; Paired Box Transcription Factors ; Receptors, Cytoplasmic and Nuclear/chemistry/genetics/*physiology ; Response Elements ; Thiazoles/pharmacology ; *Thiazolidinediones ; Thyroid Neoplasms/*genetics/metabolism ; Trans-Activators/chemistry/genetics/pharmacology/*physiology ; Transcription Factors/chemistry/genetics/pharmacology/*physiology ; Transcription, Genetic ; Transcriptional Activation ; Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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