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  • 1
    ISSN: 0021-9304
    Keywords: nanoparticles ; protein adsorption ; 2-D PAGE ; drug targeting ; colloidal drug carriers ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Plasma protein adsorption patterns on colloidal drug carriers acquired after iv administration depend on their surface characteristics and are regarded as key factors for their in vivo organ distribution. Polymeric latex particles with strongly differing surface properties were synthesized as models for colloidal drug carriers for tissue-specific drug targeting via the intravenous route. Physicochemical characterization was performed for size, surface charge density, zeta potential, and surface hydrophobicity. The interactions with human plasma proteins were studied by way of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). Considerable differences in protein adsorption on the latex particles were detected with regard to the total amount of surface-bound protein on the various particle types as well as specific proteins adsorbed, for example, fibrinogen, albumin, and a recently identified plasma glycoprotein. Possible correlations between protein adsorption patterns and the physicochemical characteristics and topography of the polymeric surfaces are shown and discussed. Knowledge about protein-nanoparticle interactions can be utilized for the rational design of colloidal drug carriers and also may be useful for optimizing implants and medical devices. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 478-485, 1998.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 13 (1900), S. 1103-1108 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0570-0833
    Keywords: Biotechnology ; Fermentation ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The preparation of organic substances with the aid of the enzyme systems of micoorganisms has become competitive as a result of recent progress in the technology of fermentation. The relatively high cost of apparatus and the lower production capacity of microbiological plants in relation to the plants used in purely chemical processes are offset in many cases by the advantages of biological methods (reactions at conventionally inactive positions in the molecule, stereospecific substitutions, coupling of several reactions, mild reaction conditions, possible use of waste products).
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    ISSN: 0887-6266
    Keywords: polypropylene ; spherulite ; cocrystallization ; lamellae ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: During spherulitic crystallization of polymers, there is a tendency for low molecular weight and other less crystallizable entities to be rejected from the body of the spherulites. This rejection process causes a segregation of these species to those areas where spherulites impinge. As a result of this segregation, lamellar and spherulite boundaries have a tendency to become weak, often resulting in premature mechanical failure. The objective of this work, anthropomorphically speaking, is to develop a melt miscible blend system in which a propylene copolymer “fools” a polypropylene homopolymer into rejecting the copolymer to the spherulite boundaries as an impurity. However, once the copolymer arrives at these boundaries, the copolymer subsequently connects adjacent spherulites through cocrystallization of the propylene copolymer segments. It was found that addition of either a random ethylene-propylene copolymer or an isotactic-atactic block copolymer was able to yield the desired effect. Cocrystallization was confirmed by calorimetry, and segregation of copolymer and subsequent reinforcement at the spherulite boundaries was directly observed microscopically. Using this approach, toughness was increased with little loss in stiffness. © 1998 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 36: 2047-2056, 1998
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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