ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Unknown

Galanin neurons in the medial preoptic area govern parental behaviour (2014)

Z. Wu ; A. E. Autry ; J. F. Bergan ; [et al.]

Nature Publishing Group (NPG)

In: Nature. 509(7500): 325-30. doi: 10.1038/nature13307.

add to mindlist on the mindlist

Details

Publication Date: 2014-05-16

Description: Mice display robust, stereotyped behaviours towards pups: virgin males typically attack pups, whereas virgin females and sexually experienced males and females display parental care. Here we show that virgin males genetically impaired in vomeronasal sensing do not attack pups and are parental. Furthermore, we uncover a subset of galanin-expressing neurons in the medial preoptic area (MPOA) that are specifically activated during male and female parenting, and a different subpopulation that is activated during mating. Genetic ablation of MPOA galanin neurons results in marked impairment of parental responses in males and females and affects male mating. Optogenetic activation of these neurons in virgin males suppresses inter-male and pup-directed aggression and induces pup grooming. Thus, MPOA galanin neurons emerge as an essential regulatory node of male and female parenting behaviour and other social responses. These results provide an entry point to a circuit-level dissection of parental behaviour and its modulation by social experience.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105201/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105201/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, Zheng -- Autry, Anita E -- Bergan, Joseph F -- Watabe-Uchida, Mitsuko -- Dulac, Catherine G -- F32 DC010089/DC/NIDCD NIH HHS/ -- R01 DC003903/DC/NIDCD NIH HHS/ -- R01 DC009019/DC/NIDCD NIH HHS/ -- R01 DC013087/DC/NIDCD NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2014 May 15;509(7500):325-30. doi: 10.1038/nature13307.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA. ; Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24828191" target="_blank"〉PubMed〈/a〉

Keywords: Aggression/physiology ; Animals ; Copulation ; Female ; Galanin/deficiency/genetics/*metabolism ; Grooming/physiology ; Male ; Maternal Behavior/*physiology ; Mice ; Neurons/*metabolism ; Optogenetics ; Paternal Behavior/*physiology ; Pheromones/analysis ; Preoptic Area/*cytology/metabolism ; TRPC Cation Channels/deficiency/genetics ; Vomeronasal Organ/physiology

Print ISSN: 0028-0836

Electronic ISSN: 1476-4687

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Published by Nature Publishing Group (NPG)

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

Unknown

Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues (2017)

Yao, Shenqin ; Bergan, Joseph ; Lanjuin, Anne ; [et al.]

eLife Sciences Publications

In: eLife. 2017; 6: Published 2017 Dec 12. doi: 10.7554/elife.31373.

add to mindlist on the mindlist

Details

Publication Date: 2017-12-12

Description: The neural control of social behaviors in rodents requires the encoding of pheromonal cues by the vomeronasal system. Here we show that the typical preference of male mice for females is eliminated in mutants lacking oxytocin, a neuropeptide modulating social behaviors in many species. Ablation of the oxytocin receptor in aromatase-expressing neurons of the medial amygdala (MeA) fully recapitulates the elimination of female preference in males. Further, single-unit recording in the MeA uncovered significant changes in the sensory representation of conspecific cues in the absence of oxytocin signaling. Finally, acute manipulation of oxytocin signaling in adults is sufficient to alter social interaction preferences in males as well as responses of MeA neurons to chemosensory cues. These results uncover the critical role of oxytocin signaling in a molecularly defined neuronal population in order to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.

Electronic ISSN: 2050-084X

Topics: Biology , Medicine , Natural Sciences in General

Published by eLife Sciences Publications

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

Unknown

Sex-specific processing of social cues in the medial amygdala (2014)

Bergan, Joseph F ; Ben-Shaul, Yoram ; Dulac, Catherine

eLife Sciences Publications

In: eLife. 2014; 3: Published 2014 Jun 03. doi: 10.7554/elife.02743.

add to mindlist on the mindlist

Details

Publication Date: 2014-06-03

Description: Animal–animal recognition within, and across species, is essential for predator avoidance and social interactions. Despite its essential role in orchestrating responses to animal cues, basic principles of information processing by the vomeronasal system are still unknown. The medial amygdala (MeA) occupies a central position in the vomeronasal pathway, upstream of hypothalamic centers dedicated to defensive and social responses. We have characterized sensory responses in the mouse MeA and uncovered emergent properties that shed new light onto the transformation of vomeronasal information into sex- and species-specific responses. In particular, we show that the MeA displays a degree of stimulus selectivity and a striking sexually dimorphic sensory representation that are not observed in the upstream relay of the accessory olfactory bulb (AOB). Furthermore, our results demonstrate that the development of sexually dimorphic circuits in the MeA requires steroid signaling near the time of puberty to organize the functional representation of sensory stimuli.

Electronic ISSN: 2050-084X

Topics: Biology , Medicine , Natural Sciences in General

Published by eLife Sciences Publications

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

Unknown

Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass (2015)

Menegas, William ; Bergan, Joseph F ; Ogawa, Sachie K ; [et al.]

eLife Sciences Publications

In: eLife. 2015; 4: Published 2015 Aug 31. doi: 10.7554/elife.10032.

add to mindlist on the mindlist

Details

Publication Date: 2015-08-31

Description: Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, cortex, amygdala, etc) in mice. We found that most populations of dopamine neurons receive a similar set of inputs rather than forming strong reciprocal connections with their target areas. A common feature among most populations of dopamine neurons was the existence of dense ‘clusters’ of inputs within the ventral striatum. However, we found that dopamine neurons projecting to the posterior striatum were outliers, receiving relatively few inputs from the ventral striatum and instead receiving more inputs from the globus pallidus, subthalamic nucleus, and zona incerta. These results lay a foundation for understanding the input/output structure of the midbrain dopamine circuit and demonstrate that dopamine neurons projecting to the posterior striatum constitute a unique class of dopamine neurons regulated by different inputs.

Electronic ISSN: 2050-084X

Topics: Biology , Medicine , Natural Sciences in General

Published by eLife Sciences Publications

Permalink