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  • Wiley-Blackwell  (8)
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  • 1
    Electronic Resource
    Electronic Resource
    Protein adsorption to polymer particles: Role of surface properties (1987)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 21 (1987), S. 161-171 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Adsorption isotherms of four plasma proteins (fibrinogen, IgG, human serum albumin, and bovine serum albumin) using four different types of small particles as substrates (siliconized glass, Teflon, polyvinylchloride, and Nylon-6, 6) are reported. The suspending liquid medium was phosphate-buffered saline, with a surface tension higher than that of any of the proteins. In keeping with the thermodynamic expectations for these systems, protein adsorption decreases for all solids in sequence from fibrinogen (the most hydrophobic) to IgG, human serum albumin, and bovine serum albumin (the most hydrophilic). Furthermore, the extent of protein adsorption also decreases from the low surface tension (hydrophobic) to the higher surface tension solids, again as expected on thermodynamic grounds. There is one minor yet interesting exception to the thermodynamic pattern: In spite of the slightly lower surface tension of siliconized glass, the extent of protein adsorption is slightly higher to Teflon than to siliconized glass. This result is attributed to the theoretically well known phenomenon of “screening”.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820210202
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  • 2
    Electronic Resource
    Electronic Resource
    Physical and hydrodynamic factors affecting erythrocyte adhesion to polymer surfaces (1988)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 22 (1988), S. 13-29 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Using a flow cell design which ensures fully developed laminar flow, the influence of various hydrodynamic and physical factors in determining the extent of erythrocyte adhesion to various polymer surfaces has been examined. Specifically we have investigated the effect of exposure time, flow rate, erythrocyte concentration, and substrate surface tension on the extent of erythrocyte adhesion. The results indicate: (1) the extent of erythrocyte adhesion is most extensive on the more hydrophobic surfaces; (2) the rate of adhesion is higher on the more hydrophobic surfaces; (3) saturation coverage occurs after 7-10 min of exposure to the erythrocyte suspension for all substrates examined. No „lag-time“ in the onset of adhesion was observed; (4) The level of saturation depends on the bulk erythrocyte concentration, increasing with increasing cell concentration; (5) the extent of adhesion decreases with an increase in flow rate; and (6) substrate surface defects such as roughness have a major effect on the pattern of erythrocyte adhesion.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820220104
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  • 3
    Electronic Resource
    Electronic Resource
    Human erythrocyte adhesion and spreading on protein-coated polymer surfacesThis work represents, in part, the M.A.Sc thesis of J. Steinberg. (1989)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 23 (1989), S. 591-610 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Protein adsorption is the first event which occurs when polymer surfaces are exposed to blood. The adsorption of proteins modifies the surface properties of the substrates and therefore influences subsequent cell - surface interactions. In an attempt to elucidate the fundamental mechanisms governing cell - proteinated-surface interactions, the extent of fresh human erythrocyte adhesion and spreading on protein-coated surfaces was examined. Five human serum proteins (albumin, fibrinogen, immunoglobulin G, fibronectin, and transferrin) were used at bulk concentrations ranging from 0.01 mg/mL to 50 mg/mL. Polymer substrates covering a wide range of wettability were employed. Protein adsorption significantly reduces erythrocyte adhesion and spreading on all test surfaces with minimum adhesion observed on fibrinogen: IgG 〉 albumin 〉 fibronectin 〉 transferrin 〉 fibrinogen. The extent of these effects is dependent on the nature of the adsorbed protein, the protein bulk concentration, and the surface properties of the underlying polymer substrates.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820230605
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  • 4
    Electronic Resource
    Electronic Resource
    Kinetic and thermodynamic aspects of platelet adhesion from suspension to various substrates (1980)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 499-509 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Kinetics of platelet adhesion from suspension to various substrates leads to Langmuir isotherm types of curves, both for suspensions in which the platelets were isolated by means of gel filtration as well as by centrifuging and washing. The level of platelet adhesion increases with increasing surface tension of the substrate. These results cannot be explained on the basis of the theoretical transport model of Ruckenstein et al. The plot of the platelet adhesion at equilibrium vs. γsv brings the observations in yet closer agreement with thermodynamic predictions based on free energy calculations than was found previously for the adhesion of platelets after short contact times between platelet suspension and substrate.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820140416
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  • 5
    Electronic Resource
    Electronic Resource
    The electro-osmotic actuation of implantable insulin micropumps (1983)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 17 (1983), S. 931-943 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A study using an electro-osmotic cell suitable for actuating an implantable insulin micropump showed that controlled variable flow rates in the order of 0.2 mL/day are possible. The cell functioned continuously with low energy and power requirements and long service life. The principle of operation is compatible with achieving the very low flow rates necessary if highly concentrated insulin is to be used to avoid frequent insulin reservoir refilling. An electro-osmotic cell, Ag/ AgCl/NaCl(aq)/ cation exchange membrane/NaCl(aq)/ AgCl/ Ag, was connected to a constant current power supply which reversed the direction of the current every 10 mins causing a to-and-fro transport of fluid through the membrane. Flow rates of 0.15-0.60 μL/min were achieved with currents of 2.5-10 mA. At the low flow rate, energy consumption was 6.4 × 10-2 J/μL and peak power requirement was 〈2.0 × 10-4 W. Fluid was transported against a pressure gradient of 52 cm Hg. The cell contained a total electrolyte volume of 〈0.25 mL. The membrane showed no change in properties after 10,000 current reversals (69 days). To function as an actuator for an implantable insulin micropump, the electro-osmotic cell requires a switching and valving assembly; a suitable design for this is briefly considered.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820170605
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  • 6
    Electronic Resource
    Electronic Resource
    The role of surface thermodynamics in thromboresistance of biomaterials (1975)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 9 (1975), S. 127-142 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A thermodynamic approach to the problem of platelet adsorption out of a suspension on to a smooth and homogeneous solid surface is developed. The interfacial tension values required may be estimated from contact angle data by means of an equation of state relation. According to the thermodynamic approach the functional dependence of platelet adsorption on surface tension of the solid differs according to whether the surface tension of the platelets is smaller or larger than the surface tension of the liquid in which they are suspended. The implications of this thermodynamic approach in situations where plasma proteins are present and the biomaterials surfaces may be heterogeneous and rough are discussed. Previous analyses using the critical surface tension of wetting and other surface-related parameters are compared with the thermodynamic analysis given here.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820090203
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  • 7
    Electronic Resource
    Electronic Resource
    Comments on the origin of platelet deposition1 and on cell adhesion to biomaterial surfaces2 (1983)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 17 (1983), S. 375-381 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820170213
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetics of cell adhesion to polymer surfaces (1988)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 22 (1988), S. 215-229 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Results of the kinetics of adhesion of granulocytes as well as fresh and glutaraldehyde-fixed erythrocytes, suspended in Hanks Balanced Salt Solution (HBSS; pH 7.2, ionic strength of 0.15) to various polymeric substrates are presented. Cell adhesion increases rapidly initially and reaches a plateau value after approximately 30 minutes. There is no evidence for a lag-time in the onset of cell adhesion, suggesting that electrostatic double-layer forces are negligible under these experimental conditions. For the experiments in which the cells are suspended in HBSS, which has a surface tension larger than that of the cells, the level of cell adhesion increases with decreasing surface tension of the polymeric substrates. An additional experiment with fresh human granulocytes suspended in HBSS containing 10% dimethyl sulfoxide was also performed. The surface tension of the resulting liquid medium is below that of the cells and the pattern of adhesion is reversed, in agreement with the predictions of a thermodynamic model for cell adhesion. The slightly different behavior of siliconized glass as a substrate is discussed in terms of „screening“.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820220306
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