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  • 1
    Electronic Resource
    Electronic Resource
    Cell disintegration by rapid decompression (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 17 (1975), S. 1545-1550 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260171012
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  • 2
    Electronic Resource
    Electronic Resource
    Methoden zur Prüfung der Spannungskorrosion. Bericht für die „European Federation of Corrosion Working Party on Stress Corrosion Test Methods“ - Teil I (1972)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 23 (1972), S. 1020-1033 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In der Hoffnung, daß sich einige Irrtümer in Zukunft vermeiden lassen, werden Probleme erörtert, die mit den verschiedenen Methoden zur Prüfung der Spannungskorrosion verbunden sind, ohne dabei jedoch einen Katalog von Prüfmethoden geben zu wollen. So kann z.B. die Zeit bis zum Bruch als Meßgröße für die Empfindlichkeit zu falschen Schlußfolgerungen führen, während andererseits der Konstrukteur irregeführt werden kann, wenn er nicht darüber informiert ist, daß KIscc-Werte, wie sie mitunter aus Versuchen an angerissenen Prüfkörpern bestimmt werden, nicht so gut reproduzierbar sind wie die Konstruktionsgrößen, z. B. Streckgrenze oder Zugfestigkeit, die ihm geläufiger sind. Andere Größen, die zu Unterschieden zwischen den in verschiedenen Laboratorien erzielten Ergebnissen führen können, sind die Auswirkungen der Probenoberfläche und ihr Verhältnis zum Volumen der Prüflösung sowie die Oberflächenendbearbeitung. Auf ähnliche Weise werden hinsichtlich der Umgebungsbedingungen bei der Prüfung die Gefahren aufgezeigt, die in der Verwendung von „Standard“-Lösungen liegen. Ebenso wird auf die Notwendigkeit hingewiesen, bei der Nachahmung von betrieblichen Schadensfällen die Zusammensetzung der Angriffsmittel sowie die entsprechenden Elektrodenpotentiale genauestens nachzubilden; die Bedeutung anderer Faktoren wird gleichfalls dargelegt.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19720231112
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  • 3
    Electronic Resource
    Electronic Resource
    Methoden zur Prüfung der Spannungskorrosion. Bericht für die “European Federation of Corrosion Working Party on Stress Corrosion Test Methods” - Teil IIAnmerkung: Nach W. Rädecker u. H. Gräfen (Stahl u. Eisen 76 [1956] S. 1616/28) ist eine Erhöhung der Lebensdauer bei pH-Werten im alkalischen Bereich zwar erkennbar, jedoch eine völlige Inhibierung der Spannungsrißkorrosion von der angewandten Zugspannung abhängig und damit unsicher. (1972)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 23 (1972), S. 1124-1129 
    Details
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/maco.19720231209
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  • 4
    Electronic Resource
    Electronic Resource
    Scale-up in suspension polymerization (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 20 (1976), S. 2299-2303 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1976.070200826
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  • 5
    Electronic Resource
    Electronic Resource
    Photophysics of polymer-bound 2-(2′-hydroxyphenyl)-2H-benzotriazole photostabilizers (1988)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 26 (1988), S. 505-510 
    Details
    ISSN: 0887-6258
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1988.140261203
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  • 6
    Electronic Resource
    Electronic Resource
    Photophysics of a sulfonated 2-hydroxyphenylbenzotriazole UV absorber in solution and in polymer substrates (1987)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 25 (1987), S. 1619-1631 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The total absorption spectrum of the UV absorber sodium 2-(2′-hydroxy-5′-methylphenyl) benzotriazole sulfonate (TINS) has been resolved into contributions by two ground-state forms in acetonitrile-water solvent mixtures and hydrogen bonding polymer and protein substrates. These two ground-state species can be assigned to (i) a planar intramolecularly hydrogen bonded form which can undergo the efficient nonradiative energy dissipation process of excited-state intramolecular proton transfer (ESIPT), and (ii) a fluorescent nonplanar species in which ESIPT is effectively prevented. The mole fractions of each contributing conformer in the polymeric substrates have been estimated. In all the polymer systems studied, a significant proportion of the TINS molecules exist in the nonplanar form and thus may not contribute to photostabilization of the substrate. The proportion of nonplanar molecules varied from 11 to 86% in synthetic polymers and 20 to 41% in protein substrates.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1987.080250615
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  • 7
    Electronic Resource
    Electronic Resource
    Study of the reaction of diazomethane with dansylated amino acid derivatives by gas chromatography/mass spectrometry (1990)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1990), S. 520-522 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Since the methylation of acids with diazomethane is widely used in trace analysis, it is extremely important for those using this technique to be alert to the analysis of compounds containing other functional groups which might become methylated with high concentrations of diazomethane. We have shown that by adding an excess of diazomethane to dansylated amino acids, not only is the methyl ester formed, but the products can be further methylated. The only remaining acidic hydrogen in the molecule is the hydrogen attached to the sulfonamide nitrogen, and the mass spectrometry results indicate that the methyl ester is formed first, and the N-methylated derivative is formed with excess diazomethane.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200190810
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  • 8
    Electronic Resource
    Electronic Resource
    Prothrombin cleavage by human vascular smooth muscle cells: A potential alternative pathway to the coagulation cascade (1995)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 59 (1995), S. 514-528 
    Details
    ISSN: 0730-2312
    Keywords: prothrombin ; prethrombin 2 ; fragment 1.2 ; α-thrombin ; prothrombin activation ; serine proteinase ; human vascular smooth muscle cells ; mitogenic activity ; enzymatic activity ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Thrombin is a potent mitogen for human vascular smooth muscle cells (HVSMC) and its enzymatic activity is required for this function. The present study demonstrates that prothrombin is also mitogenic for HVSMC due to the generation of enzymatically active thrombin which occurs upon incubation of prothrombin with the cells. Analysis by SDS-PAGE, immunoblotting, and amino acid sequencing revealed that prothrombin incubated with HVSMC undergoes limited proteolysis. Prethrombin 1 was formed through cleavage at R155-S156. Cleavage at R271-T272 generated fragment 1.2 and prethrombin 2 whilst cleavage at R284-T285 yielded truncated prothrombin 2 (prethrombin 2′). However, cleavage at R320-I321 which, during prothrombin activation produces two-chain α-thrombin, was not detectable. Studies on HVSMC-conditioned medium revealed that a similar pattern of prothrombin cleavage occurred by a cell-secreted factor(s). Amidolytic activity analysis indicated that 1-3% catalytically active thrombin-like activity was generated upon incubation of prothrombin with HVSMC-conditioned medium. By treating conditioned medium with various classes of proteinase inhibitors or hirudin, it was determined that prothrombin is cleaved by a cell-derived serine proteinase-like factor(s) at R271-S272 and by α-thrombin at R155-S156 and R284-T285. Antibodies neutralising the activity of either urokinase, tissue plasminogen activator, or factor Xa failed to alter the prothrombin cleaving activity of conditioned medium. This activity which may catalyse an alternative pathway for the generation of thrombin, was eluted from a gel filtration column as a single peak with apparent molecular mass of 30-40 kDa. © 1995 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240590411
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  • 9
    Electronic Resource
    Electronic Resource
    Multiple myeloma cells and cells of the human osteoclast lineage share morphological and cell surface markers (1998)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 71 (1998), S. 559-568 
    Details
    ISSN: 0730-2312
    Keywords: plasma cell ; CD19 ; CD38 ; naphthol AS-D chloroacetate esterase ; B cells ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: This study demonstrates that the multiple myeloma cell (MMC) in its plasma cell form is morphologically indistinguishable from human osteoclast-like cells that form in culture when peripheral blood mononuclear cells (PBMCs) are plated at high density in serum containing medium. MM has been described as a disease of B-cell lineage, monoclonal immunoglobulin (Ig) producing cells with unique properties: MM precursor cells lodge in bone, where they proliferate and differentiate into plasma cell tumors. Then, by some mechanism, presumably involving cytokines, these cells mediate an increase in neighboring osteoclast numbers and activity, leading to excessive bone erosion and hypercalcemia. Three days after plating PBMCs, tartrate resistant acid phosphatase- (TRAP-) blasts as well as TRAP+ cells, each with an eccentric nucleus, appear in culture. By day 10, TRAP+, vitronectin+ (VR+) cells, appear to be morphologically indistinguishable from multiple myeloma plasma cells (MMPCs) on cytocentrifuge preparations. These cells are CD19- and CD38++, as are MMCs reported by others. Other surface markers are also shared. Furthermore, Ig mRNA is demonstrated in the cytoplasm of cells at 8 days by in situ hybridization with the IgG FcA3 sequence. This novel finding is not unusual, in light of reports, demonstrating non-B-lineage Ig-producing cells. Thus, this study raises some serious questions about the true nature of MMCs. J. Cell. Biochem. 71:559-568, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Pathology of ovarian cancer precursors (1995)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 59 (1995), S. 208-218 
    Details
    ISSN: 0730-2312
    Keywords: Carcinoma ; ovary ; pathology ; precursor lesions ; surface epithelium ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Ninety percent of ovarian cancers in the Western world are epithelial cancers derived from the surface epithelium of the ovary and its inclusion cysts. The so-called surface epithelium in mesothelium that comes to resemble epithelium as it is reflected over the surfaces of the ovaries. At various ages, but particularly in women in the reproductive, menopausal, and postmenopausal age groups, this epithelium migrates into the ovarian stroma to form inclusion cysts. These cysts probably result from a dynamic interplay of surface epithelium and underlying ovarian stroma, but can also develop as a result of periovarian adhensions. There is abundant evidence that their formation is not related to repair of ovulation. It is generally accepted that benign and malignant ovarian epithelial tumors arise from surface epithelium and its cystic derivatives becasuse they both, but particularly the latter, have a potential to differentiate into epithelia similar to those of normal müllerian derivation (tubal, endometrial, and endocervical epithelia) and their tumors resemble those of the fallopian tube, endometrium, and endocervix. Also, both intraepithelial carcinomas and precarcinomatous lesions can be observed in the surface epithelium and its cystic derivatives. These carcinomas may arise de novo or as a transformation of pre-existing benign tumors and non-neoplastic lesions of similar derivation. Surface, epithelial inclusions cysts have a greater propensity to undergo neoplasis than does the surface epithelium itself. This difference has been recognized for many years because most epithelial ovarian tumors are intraparenchymal, rather than being located on the ovarian surface. More recent evidence includes the immunohistochemical demonstration of various carcinoma antingens far more frequently in inclusion cyst epithelium than in surface epithelium; and the much more frequent presence of tubal metaplasis in the cyst epithelium than in the surface epithelium. Tubal metaplasis is encountered in non-neoplastic ovaries contralateral to ovarian carcinomas two to three times as frequently as in control ovaries, suggesting that the metaplastic epithelium is more prone to the development of carcinoma that non-metaplastic epithelium. Carcinoma precursors occur in the ovary, as in the carvix and endometrium, but have been reported only rarely because they are easily overlooked and have not been searched for by pathologists.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240590928
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