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  • 1
    Electronic Resource
    Electronic Resource
    P57KIP2 targeted disruption and beckwith-wiedemann syndrome: Is the inhibitor just a contributor? (1997)
    New York, NY : Wiley-Blackwell
    BioEssays 19 (1997), S. 839-842 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Beckwith-Wiedemann syndrome is a human congenital disorder characterized by a wide variety of growth abnormalities, including developmental defects and predisposition to certain tumors. Genetic evidence has suggested a role for p57KIP2, a member of a family of cell cycle inhibitory genes, in Beckwith-Wiedemann syndrome. Two independent groups(1,2) have reported the generation and characterization of mice lacking functional p57KIP2, These mice demonstrate a number of abnormal phenotypes which overlap with, although do not completely recapitulate, Beckwith-Wiedemann syndrome. These findings advance the molecular characterization of a human disorder, and provide insight into the interplay between regulation of cell division and development.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950191002
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  • 2
    Electronic Resource
    Electronic Resource
    The thermal decomposition of peroxyacetic nitric anhydride (PAN) and peroxymethacrylic nitric anhydride (MPAN) (1992)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 24 (1992), S. 297-307 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rate coefficients of thermal decomposition of peroxyacetic nitric anhydride (PAN) and peroxymethacrylic nitric anhydride (MPAN) were measured over the temperature range 302-323 K. The resulting Arrhenius expressions were k = 1017.4±0.4 exp(-28.5 ± 0.5/RT) for PAN, and k = 1016.2±0.7 exp(-26.8 ± 1.0/RT) for MPAN, where the activation energy is in Kcal/mol. These results are in good agreement with previous studies of PAN and other PAN-type compounds, and imply that energies of RC(O)OO—NO2 bonds are relatively independent of the nature of R.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550240307
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