ISSN:
0749-1581
Keywords:
Octahydro-7aH-quino[1,2-c][1,3]benzoxazines
;
Perhydropyrido[1,2-c][1,3]benzoxazines
;
1H and 13C NMR
;
Conformation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The positions of conformational equilibria in the four diastereoisomers of 8,9,11,11a,11b,12,13-octahydro-7aH-quino [1,2-c] [1,3] benzoxazines were investigated using 13C and 1H NMR spectroscopy. Comparison of the NMR chemical shifts of these isomers with those in the corresponding isomers of perhydropyrido [1,2-c] [1,3]benzoxazine shows the effect on NMR shifts of fusion of the aromatic ring on to the fully saturated system. The Δδ values are discussed in terms of degree of overlap of the nitrogen lone pair orbitals with the aromatic π-system.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260310516
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