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  • Oxford University Press  (985)
  • Wiley-Blackwell  (515)
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  • 1
    Electronic Resource
    Electronic Resource
    Genetic analysis of induced deletions and of spontaneous nondisjuction involving chromosome 2 of the mouse (1960)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 56 (1960), S. 169-188 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030560415
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of histamine on the growth of cultured fibroblasts isolated from normal and keloid tissue (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 93 (1977), S. 389-393 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cultured fibroblasts derived from human keloid tissue are presented as a possible model system for studying the genetic regulation of cell growth. Histamine is shown to have a marked effect on the growth of cultured fibroblasts. A small increase in growth rate is seen during the log phase of the culture cycle and a 50% increase in cell number is observed during the plateau phase. Differences in the extent of growth stimulation are observed between strains isolated from different individuals. While most strains showed approximately 50% stimulation, a few were not stimulated and some strains gave a 100% or greater increase in cell number due to histamine. This phenotypic difference in extent of growth stimulation in response to histamine cannot be attributed to the gene or genes for keloid formation. However, elevated levels of histamine in vivo may be a contributing factor to the abnormal cell growth observed in this disorder. The extent of growth stimulation due to histamine decreases with repeated subculturing.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040930310
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  • 3
    Electronic Resource
    Electronic Resource
    Differential effects of hydrocortisone on both growth and collagen metabolism of human fibroblasts from normal and keloid tissue (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 97 (1978), S. 221-229 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cultured fibroblasts isolated from normal and keloid tissue do not differ in their growth characteristics or in the rate of collagen synthesis under routine culture conditions. The addition of hydrocortisone to the culture media results in significant differences in both growth and collagen synthesis between these cell types. Collagen syntehsis is inhibited 60% in normal cultures by hydrocortisone (0.5 μg/ml) and the population size at which density-dependent growth inhibition is achieved is increased. Keloid-derived fibroblasts grow to a lower maximum density in the presence of hydrocortisone, while their rate of collagen syntehsis is not significantly reduced. The rate of non-collagen protein synthesis is increased significantly by hydrocortisone in both cell types.Comparison of normal and keloid-derived cultures obtained from a single individual suggests that the keloid phenotype with respect to both growth and collagen synthesis is restricted to the fibroblasts isolated from the keloid nodule.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040970211
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  • 4
    Electronic Resource
    Electronic Resource
    Collagen synthesis in human fibroblasts: Effects of ascorbic acid and regulation by hydrocortisone (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 109 (1981), S. 121-131 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The effects of hydrocortisone and ascorbic acid on collagen and noncollagen protein synthesis, and on growth were examined in fibroblasts derived from normal human dermis. When the medium was supplemented with 0.28 mM ascorbic acid, the apparent rate of collagen production increased 2--3 fold over the culture cycle. Ascorbic acid also caused a small increase in the apparent rate of synthesis of noncollagen protein and an elevation in growth rate and maximum cell density. Growth was not required for the increase in collagen production since addition of ascorbate to confluent cultures induced a similar increase. Hydrocortisone (1.5 μM) blocked the ascorbate-related increase in collagen production during growth and in confluent cultures. The hormone simultaneously increased the apparent rate of noncollagen protein production and maximum cell density, suggesting that the effect on collagen synthesis was specific. Inhibition of collagen production by hydrocortisone was observed only in the presence of ascorbate, while the increase in growth and noncollagen protein production occurred in the presence and absence of the vitamin.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041090114
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  • 5
    Electronic Resource
    Electronic Resource
    An analysis of the changing radiation response of the developing mouse embryoWork performed under Contract W-7405-eng-26 for the Atomic Energy Commission. (1954)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 43 (1954), S. 103-149 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030430407
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  • 6
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    Rapid compact jet quenching in the Galactic black hole candidate X-ray binary MAXI J1535−571 (2020)
    Oxford University Press
    Details
    Publication Date: 2020-09-01
    Description: We present results from six epochs of quasi-simultaneous radio, (sub-)millimetre, infrared, optical, and X-ray observations of the black hole X-ray binary MAXI J1535−571. These observations show that as the source transitioned through the hard–intermediate X-ray state towards the soft–intermediate X-ray state, the jet underwent dramatic and rapid changes. We observed the frequency of the jet spectral break, which corresponds to the most compact region in the jet where particle acceleration begins (higher frequencies indicate closer to the black hole), evolves from the infrared band into the radio band (decreasing by ≈3 orders of magnitude) in less than a day. During one observational epoch, we found evidence of the jet spectral break evolving in frequency through the radio band. Estimating the magnetic field and size of the particle acceleration region shows that the rapid fading of the high-energy jet emission was not consistent with radiative cooling; instead, the particle acceleration region seems to be moving away from the black hole on approximately dynamical time-scales. This result suggests that the compact jet quenching is not caused by local changes to the particle acceleration, rather we are observing the acceleration region of the jet travelling away from the black hole with the jet flow. Spectral analysis of the X-ray emission shows a gradual softening in the few days before the dramatic jet changes, followed by a more rapid softening ∼1–2 d after the onset of the jet quenching.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press on behalf of The Royal Astronomical Society.
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  • 7
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    The reproducible radio outbursts of SS Cygni (2016)
    Oxford University Press
    Details
    Publication Date: 2016-06-24
    Description: We present the results of our intensive radio observing campaign of the dwarf nova SS Cyg during its 2010 April outburst. We argue that the observed radio emission was produced by synchrotron emission from a transient radio jet. Comparing the radio light curves from previous and subsequent outbursts of this system (including high-resolution observations from outbursts in 2011 and 2012) shows that the typical long and short outbursts of this system exhibit reproducible radio outbursts that do not vary significantly between outbursts, which is consistent with the similarity of the observed optical, ultraviolet and X-ray light curves. Contemporaneous optical and X-ray observations show that the radio emission appears to have been triggered at the same time as the initial X-ray flare, which occurs as disc material first reaches the boundary layer. This raises the possibility that the boundary region may be involved in jet production in accreting white dwarf systems. Our high spatial resolution monitoring shows that the compact jet remained active throughout the outburst with no radio quenching.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 8
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    Radio monitoring of the hard state jets in the 2011 outburst of MAXI J1836-194 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-04-30
    Description: MAXI J1836–194 is a Galactic black hole candidate X-ray binary that was discovered in 2011 when it went into outburst. In this paper, we present the full radio monitoring of this system during its ‘failed’ outburst, in which the source did not complete a full set of state changes, only transitioning as far as the hard intermediate state. Observations with the Karl G. Jansky Very Large Array (VLA) and Australia Telescope Compact Array (ATCA) show that the jet properties changed significantly during the outburst. The VLA observations detected linearly polarized emission at a level of ~1 per cent early in the outburst, increasing to ~3 per cent as the outburst peaked. High-resolution images with the Very Long Baseline Array (VLBA) show an ~15 mas jet along the position angle –21 ± 2°, in agreement with the electric vector position angle found from our polarization results (–21 ± 4°), implying that the magnetic field is perpendicular to the jet. Astrometric observations suggest that the system required an asymmetric natal kick to explain its observed space velocity. Comparing quasi-simultaneous X-ray monitoring with the 5 GHz VLA observations from the 2011 outburst shows an unusually steep hard-state radio/X-ray correlation of $L_{\rm R} \propto L_{\rm X}^{1.8\pm 0.2}$ , where L R and L X denote the radio and X-ray luminosities, respectively. With ATCA and Swift monitoring of the source during a period of re-brightening in 2012, we show that the system lay on the same steep correlation. Due to the low inclination of this system, we then investigate the possibility that the observed correlation may have been steepened by variable Doppler boosting.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 9
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    Using synthetic seismicity to evaluate seismic hazard in the Wellington region, New Zealand (2011)
    Oxford University Press
    Details
    Publication Date: 2011-08-27
    Description: SUMMARY A computer synthetic seismicity program for the Wellington region has been implemented and used to infer the effect of the 1848 Awatere and 1855 Wairarapa mega-earthquakes on the timing of the next characteristic (magnitude 7.35 or more) earthquake on the Wellington–Hutt Valley section of the Wellington Fault. We find that, on average over several hundred cases, a Wellington Fault event is delayed by 259 years. The synthetic catalogue of 500 000 events, magnitude 5.5 or more, also gives the average recurrence time of characteristic Wellington Fault events (960 yr) and their Coefficient of Variation (0.40). There is also a strong retarding effect on moderate magnitude Wellington Fault events, magnitude 6.5–7.3. Sensitivity tests indicate that these results are robust. The synthetic model contains 58 known major faults and 3000 randomly placed small faults to reproduce the rate and spatial distribution of background seismicity observed recently. From the synthetic catalogue it is possible to determine the average recurrence rate for all major faults. Also, there is strong evidence of the short-term (10 yr) temporal clustering of large events throughout the region, a factor that contributes to a highly variable moment release rate over time spans of a few hundred years.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 10
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    The accretion-ejection coupling in the black hole candidate X-ray binary MAXI J1836-194 (2014)
    Oxford University Press
    Details
    Publication Date: 2014-03-09
    Description: We present the results of our quasi-simultaneous radio, submm, infrared, optical and X-ray study of the Galactic black hole candidate X-ray binary MAXI J1836–194 during its 2011 outburst. We consider the full multiwavelength spectral evolution of the outburst, investigating whether the evolution of the jet spectral break (the transition between optically thick and optically thin synchrotron emission) is caused by any specific properties of the accretion flow. Our observations show that the break does not scale with the X-ray luminosity or with the inner radius of the accretion disc, and is instead likely to be set by much more complex processes. We find that the radius of the acceleration zone at the base of the jet decreases from ~10 6 gravitational radii during the hard intermediate state to ~10 3 gravitational radii as the outburst fades (assuming a black hole mass of 8 M ), demonstrating that the electrons are accelerated on much larger scales than the radius of the inner accretion disc and that the jet properties change significantly during outburst. From our broad-band modelling and high-resolution optical spectra, we argue that early in the outburst, the high-energy synchrotron cooling break was located in the optical band, between 3.2 10 14 and 4.5 10 14  Hz. We calculate that the jet has a total radiative power of 3.1 10 36  erg s –1 , which is ~6 per cent of the bolometric radiative luminosity at this time. We discuss how this cooling break may evolve during the outburst, and how that evolution dictates the total jet radiative power. Assuming the source is a stellar mass black hole with canonical state transitions, from the measured flux and peak temperature of the disc component we constrain the source distance to be 4–10 kpc.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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