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  • 1
    Electronic Resource
    Electronic Resource
    Interface effects on moisture absorption in ultrathin polyimide films (1998)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 36 (1998), S. 155-162 
    Details
    ISSN: 0887-6266
    Keywords: polyimides ; reflectivity ; moisture absorption ; Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Water absorption in thin films (〈1000 Å) of a commercial polyimide was evaluated by monitoring dimensional changes induced by a humid environment. Film thickness was measured using x-ray reflectivity, which is a nondestructive technique offering angstrom resolution in the measurements of thin film or multilayer thickness. The effect of several variables on the absorption of moisture were monitored in polyimide films adhered to polished silicon substrates, including total dry film thickness, exposure time, and the contribution of a coupling agent. The percentage increase in film thickness due to moisture uptake is found to be a weak function of dry film thickness, decreasing as dry film thickness increases, and to be somewhat affected by the use of an interfacial coupling agent. The observed behavior points to the polymer/substrate interface as a strong factor controlling the absorption of moisture in the polyimide/silicon system, and is believed to reflect the presence of a highly moisture-saturated interfacial layer. A bilayer model is proposed, and the feasibility of using this model to describe the observed behavior is considered. Published 1998 John Wiley & Sons, Inc.This article is a US Government work and, as such, is in the public domain in the United States of America. J Polym Sci B: Polym Phys 36: 155-162, 1998
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 2
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    Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa (2014)
    Oxford University Press
    Details
    Publication Date: 2014-06-10
    Description: In humans, the Crumbs homolog-1 ( CRB1 ) gene is mutated in autosomal recessive Leber congenital amaurosis and early-onset retinitis pigmentosa. In mammals, the Crumbs family is composed of: CRB1, CRB2, CRB3A and CRB3B. Recently, we showed that removal of mouse Crb2 from retinal progenitor cells, and consequent removal from Müller glial and photoreceptor cells, results in severe and progressive retinal degeneration with concomitant loss of retinal function that mimics retinitis pigmentosa due to mutations in the CRB1 gene. Here, we studied the effects of cell-type-specific loss of CRB2 from the developing mouse retina using targeted conditional deletion of Crb2 in photoreceptors or Müller cells. We analyzed the consequences of targeted loss of CRB2 in the adult mouse retina using adeno-associated viral vectors encoding Cre recombinase and short hairpin RNA against Crb2. In vivo retinal imaging by means of optical coherence tomography on retinas lacking CRB2 in photoreceptors showed progressive thinning of the photoreceptor layer and cellular mislocalization. Electroretinogram recordings under scotopic conditions showed severe attenuation of the a-wave, confirming the degeneration of photoreceptors. Retinas lacking CRB2 in developing photoreceptors showed early onset of abnormal lamination, whereas retinas lacking CRB2 in developing Müller cells showed late onset retinal disorganization. Our data suggest that in the developing retina, CRB2 has redundant functions in Müller glial cells, while CRB2 has essential functions in photoreceptors. Our data suggest that short-term loss of CRB2 in adult mouse photoreceptors, but not in Müller glial cells, causes sporadic loss of adhesion between photoreceptors and Müller cells.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 3
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    Gene therapy restores vision and delays degeneration in the CNGB1-/- mouse model of retinitis pigmentosa (2012)
    Oxford University Press
    Details
    Publication Date: 2012-09-28
    Description: Retinitis pigmentosa (RP) is a group of genetically heterogeneous, severe retinal diseases commonly leading to legal blindness. Mutations in the CNGB1a subunit of the rod cyclic nucleotide-gated (CNG) channel have been found to cause RP in patients. Here, we demonstrate the efficacy of gene therapy as a potential treatment for RP by means of recombinant adeno-associated viral (AAV) vectors in the CNGB1 knockout (CNGB1 –/– ) mouse model. To enable efficient packaging and rod-specific expression of the relatively large CNGB1a cDNA (~4 kb), we used an AAV expression cassette with a short rod-specific promoter and short regulatory elements. After injection of therapeutic AAVs into the subretinal space of 2-week-old CNGB1 –/– mice, we assessed the restoration of the visual system by analyzing (i) CNG channel expression and localization, (ii) retinal function and morphology and (iii) vision-guided behavior. We found that the treatment not only led to expression of full-length CNGB1a, but also restored normal levels of the previously degraded CNGA1 subunit of the rod CNG channel. Both proteins co-localized in rod outer segments and formed regular CNG channel complexes within the treated area of the CNGB1 –/– retina, leading to significant morphological preservation and a delay of retinal degeneration. In the electroretinographic analysis, we also observed restoration of rod-driven light responses. Finally, treated CNGB1 –/– mice performed significantly better than untreated mice in a rod-dependent vision-guided behavior test. In summary, this work provides a proof-of-concept for the treatment of rod channelopathy-associated RP by AAV-mediated gene replacement.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 4
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    The equipartition magnetic field formula in starburst galaxies: accounting for pionic secondaries and strong energy losses (2013)
    Oxford University Press
    Details
    Publication Date: 2013-03-23
    Description: Equipartition arguments provide an easy way to find a characteristic scale for the magnetic field from radio emission by assuming that the energy densities in cosmic rays and magnetic fields are the same. Yet most of the cosmic ray content in star-forming galaxies is in protons, which are invisible in radio emission. Therefore, the argument needs assumptions about the proton spectrum, typically that of a constant proton/electron ratio. In some environments, particularly starburst galaxies, the reasoning behind these assumptions does not necessarily hold: secondary pionic positrons and electrons may be responsible for most of the radio emission, and strong energy losses can alter the proton/electron ratio. We derive an equipartition expression that should work in a hadronic loss-dominated environment like starburst galaxies. Surprisingly, despite the radically different assumptions from the classical equipartition formula, numerically the results for starburst magnetic fields are similar. We explain this fortuitous coincidence using the energetics of secondary production and energy loss times. We show that these processes cause the proton/electron ratio to be ~100 for GHz-emitting electrons in starbursts.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 5
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    In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death (2012)
    Oxford University Press
    Details
    Publication Date: 2012-12-01
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 6
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    Multiproxy record for the last 4500 years from Lake Shkodra (Albania/Montenegro) (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2022-06-10
    Description: A multi-proxy record is presented for approximately the last 4500 cal a BP from Lake Shkodra, Albania/Montenegro. Lithological analyses, C/N ratio and δ13C of the organic and inorganic carbon component suggest that organic matter and bulk carbonate are predominantly authigenic. The δ18O record of bulk carbonate indicates the presence of two prominent wet periods: one at ca. 4300 cal a BP and one at ca. 2500–2000 cal a BP. The latter phase is also found in southern Spain and Central Italy, and represents a prominent event in the western and central Mediterranean. In the last 2000 years, four relatively wet intervals occurred between ca. 1800 and 1500 cal a BP (150–450 AD), 1350–1250 (600–700 AD), 1100–800 (850–1150 AD), and at ca. 90 cal a BP (1860 AD). Between ca. 4100 and 2500 cal a BP δ18O values are relatively high, with three prominent peaks indicating drier conditions at ca. 4100–4000 cal a BP, ca. 3500 and at ca. 3300 cal a BP. Four additional drier events are identified at 1850 (ca. 100 AD), 1400 (ca. 550 AD), 1150 (800 AD) and ca.750 cal a BP (1200 AD). The pollen record does not show changes in accordance with these episodes owing to the poor sensitivity of vegetation in this area, which is dominated by an orographic rainfall effect and where changes in altitudinal vegetation belts do not affect the pollen rain in the lake catchment. However, since ca. 900 cal a BP a significant decrease in the percentage arboreal pollen and in pollen concentrations suggest major deforestation produced by human activities. Copyright © 2012 John Wiley & Sons, Ltd.
    Description: Published
    Description: 780-789
    Description: 3.7. Dinamica del clima e dell'oceano
    Description: JCR Journal
    Description: reserved
    Keywords: Lake Shkodra ; late Holocene ; Mediterranean ; palaeoclimate ; stable isotopes ; 03. Hydrosphere::03.01. General::03.01.06. Paleoceanography and paleoclimatology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 7
    Electronic Resource
    Electronic Resource
    Ueber einige Orthonitrobenzylverbindungen (1893)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 47 (1893), S. 397-400 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.18930470131
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  • 8
    Electronic Resource
    Electronic Resource
    Untersuchungen über die Weine und andre gegohrne Getränke (1835)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 5 (1835), S. 228-245 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.18350050127
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  • 9
    Electronic Resource
    Electronic Resource
    Ueber die Einwirkung von Chlor auf o-Nitrotoluol bei Gegenwart von Schwefel (1892)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 25 (1892), S. 2445-2446 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.18920250246
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  • 10
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    Alu-mediated diverse and complex pathogenic copy-number variants within human chromosome 17 at p13.3 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-06-23
    Description: Alu repetitive elements are known to be major contributors to genome instability by generating Alu -mediated copy-number variants (CNVs). Most of the reported Alu -mediated CNVs are simple deletions and duplications, and the mechanism underlying Alu – Alu -mediated rearrangement has been attributed to non-allelic homologous recombination (NAHR). Chromosome 17 at the p13.3 genomic region lacks extensive low-copy repeat architecture; however, it is highly enriched for Alu repetitive elements, with a fraction of 30% of total sequence annotated in the human reference genome, compared with the 10% genome-wide and 18% on chromosome 17. We conducted mechanistic studies of the 17p13.3 CNVs by performing high-density oligonucleotide array comparative genomic hybridization, specifically interrogating the 17p13.3 region with ~150 bp per probe density; CNV breakpoint junctions were mapped to nucleotide resolution by polymerase chain reaction and Sanger sequencing. Studied rearrangements include 5 interstitial deletions, 14 tandem duplications, 7 terminal deletions and 13 complex genomic rearrangements (CGRs). Within the 17p13.3 region, Alu – Alu -mediated rearrangements were identified in 80% of the interstitial deletions, 46% of the tandem duplications and 50% of the CGRs, indicating that this mechanism was a major contributor for formation of breakpoint junctions. Our studies suggest that Alu repetitive elements facilitate formation of non-recurrent CNVs, CGRs and other structural aberrations of chromosome 17 at p13.3. The common observation of Alu -mediated rearrangement in CGRs and breakpoint junction sequences analysis further demonstrates that this type of mechanism is unlikely attributed to NAHR, but rather may be due to a recombination-coupled DNA replicative repair process.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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