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  • Wiley-Blackwell  (515)
  • Copernicus  (447)
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  • 1
    Electronic Resource
    Electronic Resource
    Genetic analysis of induced deletions and of spontaneous nondisjuction involving chromosome 2 of the mouse (1960)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 56 (1960), S. 169-188 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030560415
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of histamine on the growth of cultured fibroblasts isolated from normal and keloid tissue (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 93 (1977), S. 389-393 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cultured fibroblasts derived from human keloid tissue are presented as a possible model system for studying the genetic regulation of cell growth. Histamine is shown to have a marked effect on the growth of cultured fibroblasts. A small increase in growth rate is seen during the log phase of the culture cycle and a 50% increase in cell number is observed during the plateau phase. Differences in the extent of growth stimulation are observed between strains isolated from different individuals. While most strains showed approximately 50% stimulation, a few were not stimulated and some strains gave a 100% or greater increase in cell number due to histamine. This phenotypic difference in extent of growth stimulation in response to histamine cannot be attributed to the gene or genes for keloid formation. However, elevated levels of histamine in vivo may be a contributing factor to the abnormal cell growth observed in this disorder. The extent of growth stimulation due to histamine decreases with repeated subculturing.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040930310
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  • 3
    Electronic Resource
    Electronic Resource
    Differential effects of hydrocortisone on both growth and collagen metabolism of human fibroblasts from normal and keloid tissue (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 97 (1978), S. 221-229 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Cultured fibroblasts isolated from normal and keloid tissue do not differ in their growth characteristics or in the rate of collagen synthesis under routine culture conditions. The addition of hydrocortisone to the culture media results in significant differences in both growth and collagen synthesis between these cell types. Collagen syntehsis is inhibited 60% in normal cultures by hydrocortisone (0.5 μg/ml) and the population size at which density-dependent growth inhibition is achieved is increased. Keloid-derived fibroblasts grow to a lower maximum density in the presence of hydrocortisone, while their rate of collagen syntehsis is not significantly reduced. The rate of non-collagen protein synthesis is increased significantly by hydrocortisone in both cell types.Comparison of normal and keloid-derived cultures obtained from a single individual suggests that the keloid phenotype with respect to both growth and collagen synthesis is restricted to the fibroblasts isolated from the keloid nodule.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040970211
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  • 4
    Electronic Resource
    Electronic Resource
    Collagen synthesis in human fibroblasts: Effects of ascorbic acid and regulation by hydrocortisone (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 109 (1981), S. 121-131 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The effects of hydrocortisone and ascorbic acid on collagen and noncollagen protein synthesis, and on growth were examined in fibroblasts derived from normal human dermis. When the medium was supplemented with 0.28 mM ascorbic acid, the apparent rate of collagen production increased 2--3 fold over the culture cycle. Ascorbic acid also caused a small increase in the apparent rate of synthesis of noncollagen protein and an elevation in growth rate and maximum cell density. Growth was not required for the increase in collagen production since addition of ascorbate to confluent cultures induced a similar increase. Hydrocortisone (1.5 μM) blocked the ascorbate-related increase in collagen production during growth and in confluent cultures. The hormone simultaneously increased the apparent rate of noncollagen protein production and maximum cell density, suggesting that the effect on collagen synthesis was specific. Inhibition of collagen production by hydrocortisone was observed only in the presence of ascorbate, while the increase in growth and noncollagen protein production occurred in the presence and absence of the vitamin.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041090114
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  • 5
    Electronic Resource
    Electronic Resource
    An analysis of the changing radiation response of the developing mouse embryoWork performed under Contract W-7405-eng-26 for the Atomic Energy Commission. (1954)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 43 (1954), S. 103-149 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030430407
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  • 6
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    A multiphase CMAQ version 5.0 adjoint (2020)
    Copernicus
    Details
    Publication Date: 2020-07-02
    Description: We present the development of a multiphase adjoint for the Community Multiscale Air Quality (CMAQ) model, a widely used chemical transport model. The adjoint model provides location- and time-specific gradients that can be used in various applications such as backward sensitivity analysis, source attribution, optimal pollution control, data assimilation, and inverse modeling. The science processes of the CMAQ model include gas-phase chemistry, aerosol dynamics and thermodynamics, cloud chemistry and dynamics, diffusion, and advection. Discrete adjoints are implemented for all the science processes, with an additional continuous adjoint for advection. The development of discrete adjoints is assisted with algorithmic differentiation (AD) tools. Particularly, the Kinetic PreProcessor (KPP) is implemented for gas-phase and aqueous chemistry, and two different automatic differentiation tools are used for other processes such as clouds, aerosols, diffusion, and advection. The continuous adjoint of advection is developed manually. For adjoint validation, the brute-force or finite-difference method (FDM) is implemented process by process with box- or column-model simulations. Due to the inherent limitations of the FDM caused by numerical round-off errors, the complex variable method (CVM) is adopted where necessary. The adjoint model often shows better agreement with the CVM than with the FDM. The adjoints of all science processes compare favorably with the FDM and CVM. In an example application of the full multiphase adjoint model, we provide the first estimates of how emissions of particulate matter (PM2.5) affect public health across the US.
    Print ISSN: 1991-959X
    Electronic ISSN: 1991-9603
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 7
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    The Hominin Sites and Paleolakes Drilling Project: inferring the environmental context of human evolution from eastern African rift lake deposits (2016)
    Copernicus
    Details
    Publication Date: 2016-02-19
    Description: The role that climate and environmental history may have played in influencing human evolution has been the focus of considerable interest and controversy among paleoanthropologists for decades. Prior attempts to understand the environmental history side of this equation have centered around the study of outcrop sediments and fossils adjacent to where fossil hominins (ancestors or close relatives of modern humans) are found, or from the study of deep sea drill cores. However, outcrop sediments are often highly weathered and thus are unsuitable for some types of paleoclimatic records, and deep sea core records come from long distances away from the actual fossil and stone tool remains. The Hominin Sites and Paleolakes Drilling Project (HSPDP) was developed to address these issues. The project has focused its efforts on the eastern African Rift Valley, where much of the evidence for early hominins has been recovered. We have collected about 2 km of sediment drill core from six basins in Kenya and Ethiopia, in lake deposits immediately adjacent to important fossil hominin and archaeological sites. Collectively these cores cover in time many of the key transitions and critical intervals in human evolutionary history over the last 4 Ma, such as the earliest stone tools, the origin of our own genus Homo, and the earliest anatomically modern Homo sapiens. Here we document the initial field, physical property, and core description results of the 2012–2014 HSPDP coring campaign.
    Print ISSN: 1816-8957
    Electronic ISSN: 1816-3459
    Topics: Geosciences
    Published by Copernicus on behalf of International Continental Scientific Drilling Program.
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  • 8
    Electronic Resource
    Electronic Resource
    Rates of flow through microporous solids (1958)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 4 (1958), S. 90-96 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Rates of flow of pure gases, both those with no adsorption and those with appreciable adsorption, were studied as a function of pressure level, pressure drop, and temperature for flow through 1/2-in.-diameter cylindrical plugs of activated carbon and of unsintered Vycor glass. Adsorption isotherms for the pure gases on Vycor glass were measured over the range of variables covered in the flow studies. A few measurements were made for bulk liquid flowing through a Vycor plug.Permeabilities, which are proportional to the rate of flow per unit of pressure drop, were satisfactorily correlated for hydrogen, helium, argon, and nitrogen by employing existing gas-phase flow theory. Permeabilities considerably larger than the values predicted from the nonadsorbed gas correlation, sometimes more than seventeen times as large, were observed for ethylene, propylene, and isobutane flowing through a Vycor plug. For the hydrocarbon-Vycor systems, permeabilities for vapor flow are as much as sixty times larger than for bulk liquid flow.The unusual flow phenomena for the hydrocarbon-Vycor systems are attributed to a rapid transport in the adsorbed layer. The total transport is treated as being the sum of gas-phase and adsorbed-layer flow. An equation describing adsorbed-layer movement is derived by utilizing a force balance together with thermodynamic principles. The resulting equation has just one empirical constant, and its use requires adsorption-isotherm data. It correlates very well the surface flow rates for the major range of the variables covered in this investigation. Rate measurements were made for adsorbed-layer concentrations ranging from about one tenth of a monolayer up through the capillary condensation region. Deviations in the one constant form of the equation are observed below one tenth of a monolayer. The available literature data on flow in adsorbed layers are reasonably well correlated by the same equation.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690040117
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  • 9
    Electronic Resource
    Electronic Resource
    An experimental study of surface cooling by bubbles during nucleate boiling of water (1964)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 10 (1964), S. 656-660 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: By using a special surface thermocouple Moore and Mesler have measured large temperature fluctuations during nucleate boiling of water on chromel P surface. They found that the temperature dropped 20° to 30°F. in about 2 msec. but required 10 to 20 msec. to recover. They have postulated that the surface was cooled during initial bubble growth by evaporation of a microlayer into the bubble. To test this hypothesis a technique was developed to photograph a bubble growing from an artificial site as the surface temperature was measured.Temperature fluctuations were recorded on an oscilloscope which automatically triggered the bubble photographs by means of a time delay unit and flash tube. Photographs of bubbles were taken at 1 μsec. exposure time and ranged from about 10 μsec. after the start of the temperature drop to about 1 msec. before the start of another cycle. The photographs show that the surface cools during bubble growth and recovers during bubble departure.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690100516
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of surface orientation on delay time of bubbles from artificial sites during nucleate boiling (1967)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 13 (1967), S. 1020-1024 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690130536
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