ALBERT

Description: The effect of grain size on mantle viscosity is comparable to that of temperature and pressure. The current 3-D distribution of grain size in the mantle is however unknown. To explore the possible variability of grain size, we use: geodynamic inferences of effective viscosity, vacancy diffusion rates in upper-mantle minerals and perovspkite in the lower mantle, lateral variations in temperature derived from seismic images, and different geotherms. An important outcome of this modeling is a new mapping of lateral viscosity variations throughout the mantle. The corresponding 3-D variations in grain size are characterized by two order of magnitude changes. We find a correlation between grain size variability in the mantle and absolute viscosity changes with depth. Our findings suggest that the traditional assumption of Arrhenius temperature dependence for vacancy diffusion in the lower mantle is not sufficient to constrain the deformation mechanisms that determine its effective bulk viscosity.

Description: In order to test the hypothesis that seismic anisotropy in the lowermost mantle is caused by the development of a post-perovskite lattice preferred orientation, and that anisotropy can thus be used as a probe of the dynamics of the mantle's lower boundary layer, an integrated model of texture generation in D″ is developed. This is used to predict the elastic anisotropy of the lowermost mantle as probed by global anisotropic tomographic inversions. The model combines the current 3D mantle flow field with simulations of the deformation of post-perovskite polycrystalline aggregates. Different descriptions of single crystal plasticity can lead to model results which are anti-correlated to each other. In models where post-perovskite deformation is accommodated by dislocations moving on (010) or (100), patterns of anisotropy are approximately correlated with the results of tomographic inversions. On the other hand, in models where dislocations move on (001) patterns of anisotropy are nearly anti-correlated with tomographic inversions. If all the seismic anisotropy in D″ extracted from global anisotropic inversions is due to the presence of a lattice preferred orientation in post-perovskite in the lowermost mantle, and if the results of the tomographic inversions are not strongly biased by the sampling geometries, these results suggest that, in contrast to ideas based on the 1D anisotropic signal, deformation of post-perovskite in the lowermost mantle may be accommodated by dislocations moving on (010) or (100). Alternatively, a significant portion of the anisotropic signal may be caused by mechanisms other than the alignment of post-perovskite crystals.

Description: The Greater Caucasus Mountains, due to their youth (~5 Ma), provide an opportunity for insight into the early stages of orogen development during continent-continent collision. However, their recent tectonic evolution and first-order architecture remain unclear. Here we investigate the evolution of the orogen by integrating new observations of the fluvial geomorphology and neotectonics of the range with prior work on seismicity, geodetic strain, bedrock geology and foreland-basin structure. We find that the range contains four zones along strike that differ in structural architecture, topography, and first-order tectonic history. In particular, two south-directed, singly-vergent zones at the western and eastern tips of the orogen are separated by both a central doubly-vergent zone that is dominated by north-directed deformation, and an eastern doubly-vergent zone in which south-directed thrusting dominates. We hypothesize that the along-strike changes in vergence and locus of deformation reflects different stages in the development of a doubly-vergent orogen, with the tips of the range preserving an early, singly-vergent form and the center recording a more advanced orogen. The differences between the two-doubly vergent zones seem to be driven by the initial stages of collision between the structurally thickened crust of the Greater and Lesser Caucasus orogens, which initiated at ~5 Ma.

Description: ABSTRACT Variation in the erodibility of rock units has long been recognized as an important determinant of landscape evolution but has been little studied in landscape evolution models. We use a modified version of the CHILD landscape evolution model, which explicitly allows for variations in rock strength, to reveal and explore the remarkably rich, complex behavior induced by rock erodibility variations in even very simple geologic settings with invariant climate and tectonics. We study the importance of relative contrasts in erodibility between just two units, the order of these units (whether hard rocks overlie soft or soft rocks overlay hard) and the orientation of the contact between the two units. We emphasize the spatial and temporal evolution of erosion rates, which have important implications for basin analysis, detrital mineral records, and the interpretation of cosmogenic isotope concentrations in detrital samples. Results of the landscape evolution modeling indicate that the stratigraphic order of units in terms of erodibility, the gross orientation of the contact (i.e. dipping away or toward the outlet of the landscape) and the contact dip angle all have measurable effects on landscape evolution, including significant spatial and temporal variations in erosion rates. Steady-state denudation conditions are unlikely to develop in landscapes with significant contrasts in rock strength in horizontal to moderately tilted rock layers, at least at the scale of the entire landscape. Additionally, our results demonstrate that there is no general relation between rock erodibility and erosion rates in natural settings. Although rock erodibility directly controls the erosion rate constant in our models, it is not uncommon for higher erosion rates to occur in the harder, less erodible. Indeed erosion rates may be either greater or less than the rock uplift rate (invariant in time and space in our models) in both hard and soft rocks, depending on the local geology, topography, and the pattern of landscape evolution. This article is protected by copyright. All rights reserved.

Description: Osteosarcoma is the second leading cause of cancer-related death for children and young adults. In this study, we have subcutaneously injected –with and without matrigel- athymic mice (Fox1nu/nu) with human osteosarcoma 3AB-OS pluripotent Cancer stem cells (CSCs), which we previously isolated from human osteosarcoma MG63 cells. Engrafted 3AB-OS cells were highly tumorigenic and matrigel greatly accelerated both tumor engraftment and growth rate. 3AB-OS CSC xenografts lacked crucial regulators of beta-catenin levels (E-cadherin, APC and GSK-3beta), and crucial factors to restrain proliferation, resulting therefore in a strong proliferation potential. During the first weeks of engraftment 3AB-OS-derived tumors expressed high levels of pAKT, beta1-integrin and pFAK, nuclear beta-catenin, c-Myc, cyclin D2, along with high levels of hyperphosphorylated-inactive pRb and antiapoptotic proteins such as Bcl-2 and XIAP, and matrigel increased the expression of proliferative markers. Thereafter 3AB-OS tumor xenografts obtained with matrigel coinjection showed decreased proliferative potential and AKT levels, and undetectable hyperphosphorylated pRb, whereas beta1-integrin and pFAK levels still increased. Engrafted tumor cells also showed multilineage commitment with matrigel particularly favoring the mesenchymal lineage. Concomitantly, many blood vessels and muscle fibers appeared in the tumor mass. Our findings suggest that matrigel might regulate 3AB-OS cell behavior providing adequate cues for transducing proliferation and differentiation signals triggered by pAKT, beta1-integrin and pFAK and addressed by pRb protein. Our results provide for the first time a mouse model that recapitulates in vivo crucial features of human osteosarcoma CSCs that could be used to test and predict the efficacy in vivo of novel therapeutic treatments. J. Cell. Biochem. © 2012 Wiley Periodicals, Inc.

Description: Comparison of plate convergence with the timing and magnitude of upper-crustal shortening in collisional orogens indicates both shortening deficits (200-1700 km) and significant (10-40%) plate deceleration during collision, the cause(s) for which remain debated. The Greater Caucasus Mountains, which result from post-collisional Cenozoic closure of a relict Mesozoic back-arc basin on the northern margin of the Arabia-Eurasia collision zone, help reconcile these debates. Here we use U-Pb detrital zircon provenance data and the regional geology of the Caucasus to investigate the width of the now-consumed Mesozoic back-arc basin and its closure history. The provenance data record distinct southern and northern provenance domains that persisted until at least the Miocene. Maximum basin width was likely ~350-400 km. We propose that closure of the back-arc basin initiated at ~35 Ma, coincident with initial (soft) Arabia-Eurasia collision along the Bitlis-Zagros suture, eventually leading to ~5 Ma (hard) collision between the Lesser Caucasus arc and the Scythian platform to form the Greater Caucasus Mountains. Final basin closure triggered deceleration of plate convergence and tectonic reorganization throughout the collision. Post-collisional subduction of such small (10 2 -10 3  km wide) relict ocean basins can account for both shortening deficits and delays in plate deceleration by accommodating convergence via subduction/underthrusting, although such shortening is easily missed if it occurs along structures hidden within flysch/slate belts. Relict-basin closure is likely typical in continental collisions in which the colliding margins are either irregularly shaped or rimmed by extensive back-arc basins and fringing arcs, such as those in the modern South Pacific.

Description: NONO is an RNA-binding protein involved in transcription, mRNA splicing, DNA repair and checkpoint activation in response to UV radiation. NONO expression has been found altered in several tumour types, including prostate, colon, breast, melanoma and in papillary renal carcinoma, in which an X chromosome inversion generates a NONO-TFE3 fusion protein. Upon such rearrangement, NONO loses its C-terminal domain. Through bioinformatics analysis, we identified a putative degron motif, known to be recognized by the Skp1-Cul1-F-box-protein (SCF) complex. Here, we evaluated how this domain could affect NONO protein biology. We showed that NONO interacts with the nuclear FBW7α isoform and its ubiquitination is regulated following modulation of the GSK3β kinase. Mutation of T428A/T432A within the degron impaired polyubiquitination upon FBW7α and GSK3β overexpression. Overall, our data suggest that NONO is likely subjected to proteasome-mediated degradation and add NONO to the list of proteins targeted by FBW7, which is itself often deregulated in cancer. This article is protected by copyright. All rights reserved

Description: Efforts to extract information about climate and tectonics from topography commonly assume that river networks are static. Drainage divides can migrate through time, however, and recent work has shown that divide mobility can potentially induce changes in river profiles comparable to changes caused by variation in rock uplift, climate, or rock properties. We use 1D river profile and 2D landscape evolution simulations to evaluate how mobile divides influence the interpretation of river profiles in tectonically active settings. We define a non-dimensional divide migration number, N Dm , as the ratio of the timescale of channel profile response to a change in drainage area ( T dA ) to the timescale of divide migration ( T Dm ). In simulations of headward divide migration, N Dm is much less than unity with no measurable perturbation of channel profiles. Only in simulations configured to induce rapid lateral divide migration are there occasional large stream capture events and zones where localized drainage area loss is fast enough to support N Dm values near unity. The rapid response of channel profiles to changes in drainage area ensures that under most conditions profiles maintain quasi-equilibrium forms and thus generally reflect spatio-temporal variation in rock uplift, climate, or rock properties even during active divide migration. This implies that channel profile form may not reliably record divide mobility, so we evaluate alternate metrics of divide mobility. In our simulations and an example in Taiwan, we find that simple measures of cross-divide contrasts in topography are more robust metrics of divide mobility than measures of drainage network topology.

Description: [1]  The Greater Caucasus are the northern most extent of the Arabia-Eurasia collision and are thought to represent the main locus of shortening within the central portion of the collision zone between 40º and 48ºE. Recent work suggests that in detail, since the Plio-Pleistocene, much of the shortening in the eastern portion of the Caucasus system has been focused within the Kura Fold-Thrust belt along the southeastern margin of the Greater Caucasus. Here we present new field mapping and stratigraphic investigations of the eastern termination of the Kura fold-thrust belt in Azerbaijan to better constrain the structural geometries, magnitude of shortening, and initiation age for this portion of the fold-thrust belt. Our work suggests that this area of the fold-thrust belt exhibits significant along-strike variations in structural style and evolution, and can effectively be divided into two distinct domains at ~48ºE. The western domain is characterized by a subcritical median surface slope and isolated folds and thrusts propagating out of sequence, whereas the eastern domain is dominated by a single duplex structure and a history of in-sequence development in a critically tapered wedge. We hypothesize that these variations result from changes in relative rates of syn-tectonic sedimentation, erosion, and convergence velocity along-strike. We find that within the western domain, the fold-thrust belt has accommodated ~12 km of total shortening. An unconformity within the western domain brackets the initiation age of this portion of the fold-thrust belt to between 1.8 and 0.88 Ma yielding permissible average shortening rates of between 6.7 and 13.6 mm/yr. Comparison of these average shortening rates to the geodetically measured shortening rate of 8 mm/yr indicate that since initiation, the fold-thrust belt has accommodated 83–100% of convergence between the Greater and Lesser Caucasus at this longitude.