Publication Date:
2014-07-16
Description:
( tert -Butyl)(dimethyl)silyl ( t BuMe 2 Si; TBS) phenyl/alkyl ethers were efficiently cleaved to the corresponding parent hydroxy compounds in good yields using catalytic amounts of Ce(SO 4 ) 2 ⋅4 H 2 O by microwave-assisted or conventional heating in MeOH. Intramolecular and competitive experiments demonstrated the chemoselective deprotection of TBS ethers in the presence of triisopropylsilyl ( i Pr 3 Si; TIPS) and ( tert -butyl)(diphenyl)silyl ( t BuPh 2 Si; TBDPS) ethers.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
Permalink