Publication Date:
2018-02-16
Description:
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL, Published online: 15 February 2018; doi:10.1038/s41467-017-02688-6 T-cell prolymphocytic leukemia (T-PLL) is a rare malignancy with a poor prognosis. Here, the authors investigate the genomic landscape, gene expression profiles and functional mechanisms in 111 patients, highlighting TCL1 overexpression and ATM aberrations as core lesions which co-operate to impair DNA damage processing.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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