Publication Date:
2015-06-17
Description:
Article C-terminal mutations in the XPB helicase subunit of TFIIH are associated with cancer. Here, using Drosophila models, the authors demonstrate C-terminally truncated Hay/XPB alleles enhance overgrowth dependent on Hfp, the orthologue of the MYC transcriptional repressor FIR. Nature Communications doi: 10.1038/ncomms8404 Authors: Jue Er Amanda Lee, Naomi C. Mitchell, Olga Zaytseva, Arjun Chahal, Peter Mendis, Amandine Cartier-Michaud, Linda M. Parsons, Gretchen Poortinga, David L. Levens, Ross D. Hannan, Leonie M. Quinn
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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