Publication Date:
2014-11-27
Description:
Article Cells cope with replication-blocking DNA lesions by translesion DNA synthesis (TLS) polymerases, including polη. Here, the authors show that NPM1 , a gene frequently mutated in acute myeloid leukaemia, protects polη from proteasomal degradation, and that NPM1 deficiency causes a TLS defect. Nature Communications doi: 10.1038/ncomms6437 Authors: Omer Ziv, Amit Zeisel, Nataly Mirlas-Neisberg, Umakanta Swain, Reinat Nevo, Nir Ben-Chetrit, Maria Paola Martelli, Roberta Rossi, Stefan Schiesser, Christine E. Canman, Thomas Carell, Nicholas E. Geacintov, Brunangelo Falini, Eytan Domany, Zvi Livneh
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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